oxophenylacetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

Base Information

Chemical Name:oxophenylacetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester
CAS No.:916525-79-6
Molecular Formula:C₂₈H₂₄F₆O₄
Molecular Weight:538.487
Hs Code.:

Synonyms:oxophenylacetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of oxophenylacetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

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Technology Process of oxophenylacetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

There total 6 articles about oxophenylacetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 916525-74-1
(1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethanol

: 611-73-4
Benzoylformic acid

: 916525-79-6
oxophenylacetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.tetasy.2006.08.017

Reference yield:

: 916525-57-0
(1R,2S)-1,2-bis-(2-trifluoromethyl-phenyl)-ethane-1,2-diol

: 916525-79-6
oxophenylacetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / 4-methylbenzenesulfonic acid monohydrate / CH₂Cl₂ / 2 h / 20 °C

2: 99 percent / NaH / dimethylformamide / 12 h / 20 °C

3: 91 percent / 4-methylbenzenesulfonic acid monohydrate / methanol / 12 h

4: 91 percent / N,N-dimethylpyridin-4-amine; N,N'-diisopropylcarbodiimide / CH₂Cl₂ / 12 h / 20 °C

With dmap; p-toluenesulfonic acid monohydrate; sodium hydride; diisopropyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2006.08.017

Reference yield:

: 1,2-bis-(2-trifluoromethyl-phenyl)-2-trimethylsilanyloxy-ethanone

: 916525-79-6
oxophenylacetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: HCl / tetrahydrofuran; H₂O / 20 °C

2: 21 percent / sodium borohydride; CeCl₃*7H₂O / ethanol / 0 - 20 °C

3: 57 percent / 4-methylbenzenesulfonic acid monohydrate / CH₂Cl₂ / 2 h / 20 °C

4: 99 percent / NaH / dimethylformamide / 12 h / 20 °C

5: 91 percent / 4-methylbenzenesulfonic acid monohydrate / methanol / 12 h

6: 91 percent / N,N-dimethylpyridin-4-amine; N,N'-diisopropylcarbodiimide / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; cerium(III) chloride; p-toluenesulfonic acid monohydrate; sodium hydride; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2006.08.017