hydroxy(phenyl)acetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

Base Information

Chemical Name:hydroxy(phenyl)acetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester
CAS No.:916525-84-3
Molecular Formula:C₂₈H₂₆F₆O₄
Molecular Weight:540.502
Hs Code.:

Synonyms:hydroxy(phenyl)acetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of hydroxy(phenyl)acetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

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Technology Process of hydroxy(phenyl)acetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

There total 7 articles about hydroxy(phenyl)acetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 916525-79-6
oxophenylacetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

: 916525-84-3
hydroxy(phenyl)acetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

Guidance literature:: With L-Selectride; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1016/j.tetasy.2006.08.017

Reference yield:

: 916525-57-0
(1R,2S)-1,2-bis-(2-trifluoromethyl-phenyl)-ethane-1,2-diol

: 916525-84-3
hydroxy(phenyl)acetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 57 percent / 4-methylbenzenesulfonic acid monohydrate / CH₂Cl₂ / 2 h / 20 °C

2: 99 percent / NaH / dimethylformamide / 12 h / 20 °C

3: 91 percent / 4-methylbenzenesulfonic acid monohydrate / methanol / 12 h

4: 91 percent / N,N-dimethylpyridin-4-amine; N,N'-diisopropylcarbodiimide / CH₂Cl₂ / 12 h / 20 °C

5: 94 percent / L-Selectride(R) / tetrahydrofuran / 1 h / -78 °C

With dmap; p-toluenesulfonic acid monohydrate; L-Selectride; sodium hydride; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2006.08.017

Reference yield:

: 1,2-bis-(2-trifluoromethyl-phenyl)-2-trimethylsilanyloxy-ethanone

: 916525-84-3
hydroxy(phenyl)acetic acid (1R,2S)-2-(2-methylpropoxy)-1,2-bis[2-(trifluoromethyl)phenyl]ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: HCl / tetrahydrofuran; H₂O / 20 °C

2: 21 percent / sodium borohydride; CeCl₃*7H₂O / ethanol / 0 - 20 °C

3: 57 percent / 4-methylbenzenesulfonic acid monohydrate / CH₂Cl₂ / 2 h / 20 °C

4: 99 percent / NaH / dimethylformamide / 12 h / 20 °C

5: 91 percent / 4-methylbenzenesulfonic acid monohydrate / methanol / 12 h

6: 91 percent / N,N-dimethylpyridin-4-amine; N,N'-diisopropylcarbodiimide / CH₂Cl₂ / 12 h / 20 °C

7: 94 percent / L-Selectride(R) / tetrahydrofuran / 1 h / -78 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; cerium(III) chloride; p-toluenesulfonic acid monohydrate; L-Selectride; sodium hydride; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2006.08.017