4--N,N-diethyl-1-piperidinecarboxamide

Base Information

• Chemical Name: 4--N,N-diethyl-1-piperidinecarboxamide
• CAS No.: 117022-60-3
• Molecular Formula: C₂₃H₂₈Cl₂N₂O₂
• Molecular Weight: 435.394

Synonyms:4--N,N-diethyl-1-piperidinecarboxamide

Chemical Property of 4--N,N-diethyl-1-piperidinecarboxamide

Chemical Property:

Purity/Quality:

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Technology Process of 4--N,N-diethyl-1-piperidinecarboxamide

There total 5 articles about 4--N,N-diethyl-1-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromochlorobenzene (106-39-8) + 1-[(diethylamino)carbonyl]-4-piperidine-carboxylic acid ethyl ester (117022-78-3) → 4--N,N-diethyl-1-piperidinecarboxamide (117022-60-3)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight;

DOI:10.1021/jm00121a022

Reference yield:

1-bromo-3-chlorobenzene (108-37-2) + 1-[(diethylamino)carbonyl]-4-piperidine-carboxylic acid ethyl ester (117022-78-3) → 4--N,N-diethyl-1-piperidinecarboxamide (117022-60-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

4-carbethoxypiperidine (1126-09-6) → 4--N,N-diethyl-1-piperidinecarboxamide (117022-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / triethylamine / CH₂Cl₂ / Ambient temperature

2: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

With magnesium; triethylamine; In dichloromethane;

DOI:10.1021/jm00121a022

upstream raw materials:

bromochlorobenzene

1-[(diethylamino)carbonyl]-4-piperidine-carboxylic acid ethyl ester

4-carbethoxypiperidine

N,N-diethylcarbamyl chloride

Downstream raw materials:

α,α-Bis(4-chlorophenyl)-4-piperidinemethanol

1-[4-(3-{4-[Bis-(4-chloro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone; compound with oxalic acid

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