2-phenyl-5-ethyl-oxazole-4-carboxylic acid (4-piperidin-4-yl-phenyl)-amide

Base Information

Chemical Name:2-phenyl-5-ethyl-oxazole-4-carboxylic acid (4-piperidin-4-yl-phenyl)-amide
CAS No.:1229419-51-5
Molecular Formula:C₂₃H₂₅N₃O₂
Molecular Weight:375.47
Hs Code.:

Synonyms:2-phenyl-5-ethyl-oxazole-4-carboxylic acid (4-piperidin-4-yl-phenyl)-amide

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Chemical Property of 2-phenyl-5-ethyl-oxazole-4-carboxylic acid (4-piperidin-4-yl-phenyl)-amide

Chemical Property:

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Technology Process of 2-phenyl-5-ethyl-oxazole-4-carboxylic acid (4-piperidin-4-yl-phenyl)-amide

There total 5 articles about 2-phenyl-5-ethyl-oxazole-4-carboxylic acid (4-piperidin-4-yl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1229419-52-6
4-{4-[(2-phenyl-5-ethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester

: 1229419-51-5
2-phenyl-5-ethyl-oxazole-4-carboxylic acid (4-piperidin-4-yl-phenyl)-amide

Guidance literature:: 4-{4-[(2-phenyl-5-ethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In ethyl acetate;

Reference yield:

: 98-88-4
benzoyl chloride

: 1229419-51-5
2-phenyl-5-ethyl-oxazole-4-carboxylic acid (4-piperidin-4-yl-phenyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 1 h / 20 °C / Cooling with ice

2: iodine; triethylamine; triphenylphosphine / tetrahydrofuran / 1.17 h / -78 - 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 1551.49 Torr

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dimethyl sulfoxide / 1 h / 20 °C

5: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With pyridine; hydrogenchloride; hydrogen; iodine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1229419-50-4
5-ethyl-2-phenyl-oxazole-4-carboxylic acid benzyl ester

: 1229419-51-5
2-phenyl-5-ethyl-oxazole-4-carboxylic acid (4-piperidin-4-yl-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 1551.49 Torr

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dimethyl sulfoxide / 1 h / 20 °C

3: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide; ethyl acetate;