(4R)-2,2-dimethyl-4-phenyl-3-<(5S)-3-phenyl-2-isoxazoline-5-carbonyl>oxazolidine

Base Information

Chemical Name:(4R)-2,2-dimethyl-4-phenyl-3-<(5S)-3-phenyl-2-isoxazoline-5-carbonyl>oxazolidine
CAS No.:139255-97-3
Molecular Formula:C₂₁H₂₂N₂O₃
Molecular Weight:350.417
Hs Code.:

Synonyms:(4R)-2,2-dimethyl-4-phenyl-3-<(5S)-3-phenyl-2-isoxazoline-5-carbonyl>oxazolidine

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Chemical Property of (4R)-2,2-dimethyl-4-phenyl-3-<(5S)-3-phenyl-2-isoxazoline-5-carbonyl>oxazolidine

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Technology Process of (4R)-2,2-dimethyl-4-phenyl-3-<(5S)-3-phenyl-2-isoxazoline-5-carbonyl>oxazolidine

There total 7 articles about (4R)-2,2-dimethyl-4-phenyl-3-<(5S)-3-phenyl-2-isoxazoline-5-carbonyl>oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 139255-94-0
(4R)-2,2-dimethyl-4-phenyl-1,3-oxazolidine

: 3-Phenyl-4,5-dihydro-isoxazole-5-carbonyl chloride

: 139255-96-2
(4R)-2,2-dimethyl-4-phenyl-3-<(5R)-3-phenyl-2-isoxazoline-5-carbonyl>oxazolidine

: 139255-97-3
(4R)-2,2-dimethyl-4-phenyl-3-<(5S)-3-phenyl-2-isoxazoline-5-carbonyl>oxazolidine

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4020(01)89440-0

Reference yield:

: 873-67-6
benzonitrile oxide

: 139255-93-9
acrylic 2,2-dimethyl-5(R)-phenyl-1,3-oxazolidinide

: 139255-98-4
(S)-3-Phenyl-4,5-dihydro-isoxazole-5-carboxylic acid (1-hydroxy-1-methyl-ethyl)-((R)-2-hydroxy-1-phenyl-ethyl)-amide

: 139255-96-2
(4R)-2,2-dimethyl-4-phenyl-3-<(5R)-3-phenyl-2-isoxazoline-5-carbonyl>oxazolidine

: 139255-97-3
(4R)-2,2-dimethyl-4-phenyl-3-<(5S)-3-phenyl-2-isoxazoline-5-carbonyl>oxazolidine

Guidance literature:: With lithium triethylborohydride; In 1,4-dioxane; at -50 ℃; Yield given. Yields of byproduct given;
DOI:10.1016/S0957-4166(00)80018-X

Reference yield:

: 4872-58-6
3-phenyl-4,5-dihydroisoxazole-5-carboxylic acid

: 139255-97-3
(4R)-2,2-dimethyl-4-phenyl-3-<(5S)-3-phenyl-2-isoxazoline-5-carbonyl>oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 6 h / Ambient temperature

2: NEt₃ / CH₂Cl₂ / 0.17 h / 0 °C

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4020(01)89440-0