phenylmethylene dihexanoate

Base Information

• Chemical Name: phenylmethylene dihexanoate
• CAS No.: 167862-24-0
• Molecular Formula: C₁₉H₂₈O₄
• Molecular Weight: 320.429
• Mol file: 167862-24-0.mol

Synonyms:phenylmethylene dihexanoate

Chemical Property of phenylmethylene dihexanoate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of phenylmethylene dihexanoate

There total 4 articles about phenylmethylene dihexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

n-hexanoic anhydride (2051-49-2) + benzaldehyde (100-52-7) → phenylmethylene dihexanoate (167862-24-0)

Guidance literature:

With toluene-4-sulfonic acid; at 20 ℃; for 12h;

DOI:10.1016/j.tet.2018.05.044

Reference yield:

benzylidene 1,1-diacetate (581-55-5) → phenylmethylene dihexanoate (167862-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 11 percent / magnesium / tetrahydrofuran / 3 h / 20 °C / ultrasound irradiation

2: 75 percent / BF₃*OEt₂ / 20 °C / salt-ice cooling

With boron trifluoride diethyl etherate; magnesium; In tetrahydrofuran; 1: Substitution / 2: Esterification;

DOI:10.1016/S0040-4020(97)00789-8

Reference yield:

α,α-dipropionoxytoluene (55696-47-4) → phenylmethylene dihexanoate (167862-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 4 percent / magnesium / tetrahydrofuran / 3 h / 20 °C / ultrasound irradiation

2: 75 percent / BF₃*OEt₂ / 20 °C / salt-ice cooling

With boron trifluoride diethyl etherate; magnesium; In tetrahydrofuran; 1: Substitution / 2: Esterification;

DOI:10.1016/S0040-4020(97)00789-8

upstream raw materials:

n-hexanoic anhydride

benzaldehyde

α,α-dipropionoxytoluene

benzylidene 1,1-diacetate

Downstream raw materials:

benzyl hexanoate

N-benzylhexanamide

rac-1-phenyl-1-propyl-propionate

α,α-dipropionoxytoluene

Refernces

• 1、 Chapman, Robert S.L.,Francis, Molly,Lawrence, Ruth,Tibbetts, Joshua D.,Bull, Steven D.. "Formyloxyacetoxyphenylmethane and 1,1-diacylals as versatile O-formylating and O-acylating reagents for alcohols". . p. 6442 - 6452. Retrieved 2018/10/02.
• 2、 -. "Pharmaceutical compositions". . . Retrieved 2008/06/13.