1-[2,5-di-O-(tert-butyldimethylsilyl)-3-C-(N-benzylcarbamoylmethyl)-β-D-ribo-pentofuranosyl]uracil

Base Information

Chemical Name:1-[2,5-di-O-(tert-butyldimethylsilyl)-3-C-(N-benzylcarbamoylmethyl)-β-D-ribo-pentofuranosyl]uracil
CAS No.:195391-30-1
Molecular Formula:C₃₀H₄₉N₃O₇Si₂
Molecular Weight:619.906
Hs Code.:

Synonyms:1-[2,5-di-O-(tert-butyldimethylsilyl)-3-C-(N-benzylcarbamoylmethyl)-β-D-ribo-pentofuranosyl]uracil

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Chemical Property of 1-[2,5-di-O-(tert-butyldimethylsilyl)-3-C-(N-benzylcarbamoylmethyl)-β-D-ribo-pentofuranosyl]uracil

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Technology Process of 1-[2,5-di-O-(tert-butyldimethylsilyl)-3-C-(N-benzylcarbamoylmethyl)-β-D-ribo-pentofuranosyl]uracil

There total 4 articles about 1-[2,5-di-O-(tert-butyldimethylsilyl)-3-C-(N-benzylcarbamoylmethyl)-β-D-ribo-pentofuranosyl]uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 195391-25-4
1-[2-O-(tert-butyldimethylsilyl)-3-C-(N-benzylcarbamoylmethyl)-β-D-ribo-pentofuranosyl]uracil

: 18162-48-6
tert-butyldimethylsilyl chloride

: 195391-30-1
1-[2,5-di-O-(tert-butyldimethylsilyl)-3-C-(N-benzylcarbamoylmethyl)-β-D-ribo-pentofuranosyl]uracil

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1039/b517602f

Reference yield:

: 162611-11-2
1-[2-O-(tert-butyldimethylsilyl)-β-D-erythro-pentofuran-3-ulosyl]uracil

: 195391-30-1
1-[2,5-di-O-(tert-butyldimethylsilyl)-3-C-(N-benzylcarbamoylmethyl)-β-D-ribo-pentofuranosyl]uracil

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / CH₂Cl₂ / -78 °C

2: 85 percent / SmI₂ / tetrahydrofuran / -78 °C

3: 80 percent / Et₃N / dimethylformamide / 7 h / 20 °C

4: 93 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; samarium diiodide; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b517602f

Reference yield:

: 186839-96-3
1-[(2R,3R,3aR,7aR)-3-(tert-Butyl-dimethyl-silanyloxy)-3a-hydroxy-5-oxo-hexahydro-furo[2,3-c]pyran-2-yl]-1H-pyrimidine-2,4-dione

: 195391-30-1
1-[2,5-di-O-(tert-butyldimethylsilyl)-3-C-(N-benzylcarbamoylmethyl)-β-D-ribo-pentofuranosyl]uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Et₃N / dimethylformamide / 7 h / 20 °C

2: 93 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1039/b517602f