4-(2-methoxy-5-nitro-4-[1-(2,2,2-trifluoroacetamido)ethyl]phenoxy)butyl acetate

Base Information

Chemical Name:4-(2-methoxy-5-nitro-4-[1-(2,2,2-trifluoroacetamido)ethyl]phenoxy)butyl acetate
CAS No.:945495-93-2
Molecular Formula:C₁₇H₂₁F₃N₂O₇
Molecular Weight:422.358
Hs Code.:

Synonyms:4-(2-methoxy-5-nitro-4-[1-(2,2,2-trifluoroacetamido)ethyl]phenoxy)butyl acetate

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Chemical Property of 4-(2-methoxy-5-nitro-4-[1-(2,2,2-trifluoroacetamido)ethyl]phenoxy)butyl acetate

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Technology Process of 4-(2-methoxy-5-nitro-4-[1-(2,2,2-trifluoroacetamido)ethyl]phenoxy)butyl acetate

There total 1 articles about 4-(2-methoxy-5-nitro-4-[1-(2,2,2-trifluoroacetamido)ethyl]phenoxy)butyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4-(2-methoxy-4-[1-(2,2,2-trifluoroacetamido)ethyl]phenoxy)butyl acetate

: 945495-93-2
4-(2-methoxy-5-nitro-4-[1-(2,2,2-trifluoroacetamido)ethyl]phenoxy)butyl acetate

Guidance literature:: With nitric acid; at 0 ℃; for 2h;
DOI:10.1039/b704587e

Reference yield: 89.0%

: 945495-93-2
4-(2-methoxy-5-nitro-4-[1-(2,2,2-trifluoroacetamido)ethyl]phenoxy)butyl acetate

: 252851-63-1
4-[4-(1-aminoethyl)-2-methoxy-5-nitrophenoxy]-1-butanol

Guidance literature:: With sodium hydroxide; In methanol; for 6h; Heating;
DOI:10.1039/b704587e

Reference yield:

: 945495-93-2
4-(2-methoxy-5-nitro-4-[1-(2,2,2-trifluoroacetamido)ethyl]phenoxy)butyl acetate

: 11-(4-methoxytritylamino)-N-(1-{4-[4-O-(2-cyanoethoxy-diisopropylaminophosphinoxy)butoxy]-3-methoxy-6-nitrophenyl}ethyl)undecanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / NaOH / methanol / 6 h / Heating

2: 86 percent / EDC*HCl / pyridine / 3 h / 20 °C

3: 73 percent / DIPEA / tetrahydrofuran / 2 h / 20 °C

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; methanol;
DOI:10.1039/b704587e