2-chloro-4-{4-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-(methyloxy)phenyl]-2-ethyl-1,3-thiazol-5-yl}pyrimidine

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Chemical Name:2-chloro-4-{4-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-(methyloxy)phenyl]-2-ethyl-1,3-thiazol-5-yl}pyrimidine
CAS No.:1126431-46-6
Molecular Formula:C₂₃H₃₀ClN₃O₂SSi
Molecular Weight:476.115
Hs Code.:

Synonyms:2-chloro-4-{4-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-(methyloxy)phenyl]-2-ethyl-1,3-thiazol-5-yl}pyrimidine

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Chemical Property of 2-chloro-4-{4-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-(methyloxy)phenyl]-2-ethyl-1,3-thiazol-5-yl}pyrimidine

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Technology Process of 2-chloro-4-{4-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-(methyloxy)phenyl]-2-ethyl-1,3-thiazol-5-yl}pyrimidine

There total 1 articles about 2-chloro-4-{4-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-(methyloxy)phenyl]-2-ethyl-1,3-thiazol-5-yl}pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.7%

: 631-58-3
thiopropanamide

: 1126431-45-5
2-(2-chloro-4-pyrimidinyl)-1-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-(methyloxy)phenyl]ethanone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1126431-46-6
2-chloro-4-{4-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-(methyloxy)phenyl]-2-ethyl-1,3-thiazol-5-yl}pyrimidine

Guidance literature:: 2-(2-chloro-4-pyrimidinyl)-1-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-(methyloxy)phenyl]ethanone; With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 0.5h;

thiopropanamide; In dimethyl sulfoxide; at 20 ℃; for 1h;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 11.0%

: 92808-20-3
6-(4-acetylpiperazin-1-yl)pyridin-3-amine

: 1126431-46-6
2-chloro-4-{4-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-(methyloxy)phenyl]-2-ethyl-1,3-thiazol-5-yl}pyrimidine

: 1126431-43-3
[4-[5-(2-{[6-(4-acetyl-1-piperazinyl)-3-pyridinyl]amino}-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl]-2-(methyloxy)phenyl]methanol

Guidance literature:: 6-(4-acetylpiperazin-1-yl)pyridin-3-amine; 2-chloro-4-{4-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-3-(methyloxy)phenyl]-2-ethyl-1,3-thiazol-5-yl}pyrimidine; In methanol; butan-1-ol; at 170 ℃; for 0.416667h; Microwave irradiation;

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; butan-1-ol; for 0.166667h;