Methyl (2R,5S)-5-(tert-butyldimethylsilyloxy)-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate

Base Information

Chemical Name:Methyl (2R,5S)-5-(tert-butyldimethylsilyloxy)-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate
CAS No.:165674-77-1
Molecular Formula:C₂₁H₃₃NO₄Si
Molecular Weight:391.583
Hs Code.:

Synonyms:Methyl (2R,5S)-5-(tert-butyldimethylsilyloxy)-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate

Suppliers and Price of Methyl (2R,5S)-5-(tert-butyldimethylsilyloxy)-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl (2R,5S)-5-(tert-butyldimethylsilyloxy)-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of Methyl (2R,5S)-5-(tert-butyldimethylsilyloxy)-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate

There total 1 articles about Methyl (2R,5S)-5-(tert-butyldimethylsilyloxy)-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13735-81-4
1-styrenyloxytrimethylsilane

: 138565-92-1,138582-69-1
methyl (2RS,5S)-5-(tert-butyldimethylsilyloxy)-2-ethoxypiperidine-1-carboxylate

: Methyl (2S,5S)-5-(tert-butyldimethylsilyloxy)-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate

: 165674-77-1
Methyl (2R,5S)-5-(tert-butyldimethylsilyloxy)-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate

Guidance literature:: With zinc(II) chloride; In dichloromethane; Yields of byproduct given. Title compound not separated from byproducts; 1.) -78 deg C to room temp., 2 h, 2.) room temp., 7 h;

Reference yield: 76.0%

: 165674-77-1
Methyl (2R,5S)-5-(tert-butyldimethylsilyloxy)-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate

: 165674-78-2
Methyl (2R,5S)-5-hydroxy-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 24h;

Reference yield:

: 165674-77-1
Methyl (2R,5S)-5-(tert-butyldimethylsilyloxy)-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate

: 112463-02-2
(+)-5-hydroxysedamine

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / 2 M HCl / tetrahydrofuran / 24 h

2: 89 percent / N(C₂H₅)3, DMAP / CH₂Cl₂ / 1.) 0 deg C to room temp., 2 h, 2.) room temp., 15 h

3: 89 percent / 18-crown-6 / toluene / 18 h / 90 - 100 °C

4: 90 percent / Li(tBuO)3AlH / tetrahydrofuran / 3 h / Heating

5: 88 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With hydrogenchloride; dmap; lithium aluminium tetrahydride; 18-crown-6 ether; lithium tri-t-butoxyaluminum hydride; triethylamine; In tetrahydrofuran; dichloromethane; toluene;