ethyl 5-{3-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}isoxazole-3-carboxylate

Base Information

Chemical Name:ethyl 5-{3-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}isoxazole-3-carboxylate
CAS No.:368453-54-7
Molecular Formula:C₁₈H₁₉N₃O₅
Molecular Weight:357.366
Hs Code.:

Synonyms:ethyl 5-{3-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}isoxazole-3-carboxylate

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Chemical Property of ethyl 5-{3-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}isoxazole-3-carboxylate

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Technology Process of ethyl 5-{3-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}isoxazole-3-carboxylate

There total 5 articles about ethyl 5-{3-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}isoxazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 14337-43-0
ethyl 2-chloro-2-(hydroxyimino)acetate

: 368453-53-6
5-methyl-3-[4-(pent-4-ynyloxy)phenyl]-1,2,4-oxadiazole

: 368453-54-7
ethyl 5-{3-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}isoxazole-3-carboxylate

Guidance literature:: ethyl 2-chloro-2-(hydroxyimino)acetate; 5-methyl-3-[4-(pent-4-ynyloxy)phenyl]-1,2,4-oxadiazole; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

With TEA; In N,N-dimethyl-formamide; at 85 ℃; for 1h; Further stages.;
DOI:10.1039/b100356i

Reference yield:

: 14267-92-6
1-chloro-4-pentyne

: 368453-54-7
ethyl 5-{3-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}isoxazole-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 99 percent / K₂CO₃; KI / dimethylformamide / 21 h / 65 °C

2.1: hydroxylamine hydrochloride; K₂CO₃ / ethanol / 18 h / Heating

3.1: 0.44 g / pyridine / 2 h / Heating

4.1: dimethylformamide / 0.5 h / 20 °C

4.2: 62 percent / TEA / dimethylformamide / 1 h / 85 °C

With pyridine; hydroxylamine hydrochloride; potassium carbonate; potassium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1039/b100356i

Reference yield:

: 767-00-0
4-cyanophenol

: 368453-54-7
ethyl 5-{3-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]propyl}isoxazole-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 99 percent / K₂CO₃; KI / dimethylformamide / 21 h / 65 °C

2.1: hydroxylamine hydrochloride; K₂CO₃ / ethanol / 18 h / Heating

3.1: 0.44 g / pyridine / 2 h / Heating

4.1: dimethylformamide / 0.5 h / 20 °C

4.2: 62 percent / TEA / dimethylformamide / 1 h / 85 °C

With pyridine; hydroxylamine hydrochloride; potassium carbonate; potassium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1039/b100356i