5-Hydroxy-2,4,6-triphenyl-1,3,5-dioxaphosphorinane 5-oxide

Base Information

• Chemical Name: 5-Hydroxy-2,4,6-triphenyl-1,3,5-dioxaphosphorinane 5-oxide
• CAS No.: 13474-66-3
• Molecular Formula: C₂₁H₁₉O₄P
• Molecular Weight: 366.353
• DSSTox Substance ID: DTXSID10928741
• Mol file: 13474-66-3.mol

Synonyms:BRN 5134026;2,4,6-triphenyl-1,3,5-dioxaphosphinan-5-ol 5-oxide;5-Hydroxy-2,4,6-triphenyl-1,3,5-dioxaphosphorinane 5-oxide;1,3,5-DIOXAPHOSPHORINANE, 5-HYDROXY-2,4,6-TRIPHENYL-, 5-OXIDE;13474-66-3;Oprea1_315631;C21H19O4P;DTXSID10928741;C21-H19-O4-P;STK095007;AKOS005395588;LS-62385;5-hydroxy-5-oxo-2,4,6-triphenyl-1,3,5-dioxaphosphorinane;5-Hydroxy-2,4,6-triphenyl-1,3,5lambda~5~-dioxaphosphinan-5-one

Chemical Property of 5-Hydroxy-2,4,6-triphenyl-1,3,5-dioxaphosphorinane 5-oxide

Chemical Property:

• Vapor Pressure: 1.71E-17mmHg at 25°C
• Boiling Point: 644.6°Cat760mmHg
• Flash Point: 343.6°C
• Density: 1.32g/cm³
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 366.10209608
• Heavy Atom Count: 26
• Complexity: 460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2OC(P(=O)(C(O2)C3=CC=CC=C3)O)C4=CC=CC=C4

Technology Process of 5-Hydroxy-2,4,6-triphenyl-1,3,5-dioxaphosphorinane 5-oxide

There total 3 articles about 5-Hydroxy-2,4,6-triphenyl-1,3,5-dioxaphosphorinane 5-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

bis-(α-hydroxyphenylmethyl)phosphinic acid (90-09-5,112162-61-5,112162-62-6) + benzaldehyde (100-52-7) → 5-hydroxy-5-oxo-2,4,6-triphenyl-1,3,5-dioxaphosphorinane (13474-66-3)

Guidance literature:

In benzene; for 24h; Heating;

DOI:10.1007/BF00963705

Reference yield: 41.0%

benzaldehyde (100-52-7) → bis-(α-hydroxyphenylmethyl)phosphinic acid (90-09-5,112162-61-5,112162-62-6) + 5-hydroxy-5-oxo-2,4,6-triphenyl-1,3,5-dioxaphosphorinane (13474-66-3)

Guidance literature:

With hypophosphorous acid; In benzene; for 3h; Heating;

DOI:10.1007/BF00963705

Reference yield:

benzaldehyde (100-52-7) → 5-hydroxy-5-oxo-2,4,6-triphenyl-1,3,5-dioxaphosphorinane (13474-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / hypophosphorous acid / benzene / 3 h / Heating

2: 88 percent / benzene / 24 h / Heating

With hypophosphorous acid; In benzene;

DOI:10.1007/BF00963705

upstream raw materials:

bis-(α-hydroxyphenylmethyl)phosphinic acid

benzaldehyde