9-phenyl-nona-2,8-diynoic acid methyl ester

Base Information

• Chemical Name: 9-phenyl-nona-2,8-diynoic acid methyl ester
• CAS No.: 289652-49-9
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.302
• Mol file: 289652-49-9.mol

Synonyms:9-phenyl-nona-2,8-diynoic acid methyl ester

Chemical Property of 9-phenyl-nona-2,8-diynoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 9-phenyl-nona-2,8-diynoic acid methyl ester

There total 1 articles about 9-phenyl-nona-2,8-diynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl chloroformate (79-22-1) + 1-(octa-1,7-diynyl)benzene (96964-47-5) → 9-phenyl-nona-2,8-diynoic acid methyl ester (289652-49-9)

Guidance literature:

1-(octa-1,7-diynyl)benzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

methyl chloroformate; In tetrahydrofuran; Further stages.;

DOI:10.1021/ol005785s

Reference yield: 81.0%

9-phenyl-nona-2,8-diynoic acid methyl ester (289652-49-9) → (Z)-3-Iodo-9-phenyl-non-2-en-8-ynoic acid methyl ester (289652-55-7)

Guidance literature:

With acetic acid; sodium iodide; at 65 ℃;

DOI:10.1021/ol005785s

Reference yield:

9-phenyl-nona-2,8-diynoic acid methyl ester (289652-49-9) → [2-[1-Phenyl-meth-(Z)-ylidene]-cyclohex-(E)-ylidene]-acetic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / NaI; HOAc / 65 °C

2: AIBN; tributyltin hydride / benzene / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; acetic acid; sodium iodide; In benzene; 1: Addition / 2: Cyclization;

DOI:10.1021/ol005785s

upstream raw materials:

methyl chloroformate

1-(octa-1,7-diynyl)benzene

Downstream raw materials:

(Z)-3-Iodo-9-phenyl-non-2-en-8-ynoic acid methyl ester