96964-47-5

Upstream product

• 76911-01-8 5-hexynyl p-toluenesulfonate 
• 4440-01-1 lithium phenylacetylide 
• 109-72-8 n-butyllithium 
• 536-74-3 phenylacetylene 
• 30964-00-2 hept-6-ynoic acid 
• 104-15-4 toluene-4-sulfonic acid 
• 928-90-5 5-hexyl-1-ol 
• 591-50-4 iodobenzene 
• 871-84-1 1,7-Octadiyne 

Downstream Products

• 96964-45-3 2-(8-phenyloctyl) benzaldehyde 
• 96964-40-8 SKF 102922 
• 127948-26-9 2-(8-phenyloctyl)-5-trifluoromethyl-benzaldehyde 
• 96964-48-6 2-(8-phenyl-1,7-octadiynyl)benzaldehyde 
• 127948-50-9 3-(8-phenyl-1,7-octadiynyl)benzaldehyde 
• 1130348-21-8 6-(8-phenylocta-1,7-diyn-1-yl)pyridine-2-carboxaldehyde 
• 1235542-66-1 2-(8-phenylocta-1,7-diyn-1-yl)quinoline-3-carboxaldehyde 
• 1370031-72-3 (5Z)-1-tert-butyl-5-(tert-butylimino)-3-(6-phenylhex-5-ynyl)-1H-pyrrol-2(5H)-one 
• 1370031-39-2 (5E)-1-tert-butyl-5-(tert-butylimino)-3-(6-phenylhex-5-ynyl)-1H-pyrrol-2(5H)-one 
• 1253521-01-5 1-(9,9-dimethylfluoren-2-yl)-8-phenyl-octa-1,7-diyne 
• 1026120-44-4 (Z)-2-[(2-methylenecyclohexylidene)(phenyl)methyl]isoindoline-1,3-dione 
• 289652-55-7 (Z)-3-Iodo-9-phenyl-non-2-en-8-ynoic acid methyl ester 

Relevant academic research and scientific papers

Iron-Catalyzed Contrasteric Functionalization of Allenic C(sp2)-H Bonds: Synthesis of α-Aminoalkyl 1,1-Disubstituted Allenes

An iron-catalyzed C-H functionalization of simple monosubstituted allenes is reported. An efficient protocol for this process was made possible by the use of a newly developed electron-rich and sterically hindered cationic cyclopentadienyliron dicarbonyl complex as the catalyst andN-sulfonyl hemiaminal ether reagents as precursors to iminium ion electrophiles. Under optimized conditions, the use of a mild, functional-group-tolerant base enabled the conversion of a range of monoalkyl allenes to their allenylic sulfonamido 1,1-disubstituted derivatives, a previously unreported and contrasteric regiochemical outcome for the C-H functionalization of electronically unbiased and directing-group-free allenes.

Graphitic Carbon Nitride Polymer as a Recyclable Photoredox Catalyst for Decarboxylative Alkynylation of Carboxylic Acids

Visible-light-induced heterogeneous photocatalysis for decarboxylative alkynylation has been performed. The using of cheap, metal-free and recyclable graphitic carbon nitride (g-C3N4) as the photoredox catalyst in the process enables

Cobalt-catalyzed intramolecular [2 + 2 + 2] cocyclotrimerization of nitrilediynes: An efficient route to tetra- And pentacyclic pyridine derivatives

In this paper, we wish to report the intramolecular [2 + 2 + 2] cocyclotrimerization of nitrilediynes catalyzed by the Col2(dppe)/Zn system at 80°C in CH3CN. Under these reaction conditions, various highly substituted nitrilediynes h

Generation of cycloalkylidene carbenes via exo-type cyclization of alkynyllithiums bearing remote leaving group

The reaction of 5-hexynyl rosylate (3a) with alkynyllithium (RC≡CLi; R = Ph, TMS) gives enynes 5 and 6. The reaction proceeds through a mechanism involving a novel exo-type cyclization of 6-lithio-5-hexynyl tosylate to form cyclopentylidene carbene. Enyne 6 is produced by the addition of RC≡CLi to the carbene, whereas rearrangement of the carbene to cyclohexyne followed by carbolithiation with RC≡CLi gives enyne 5. The formation of cyclopentylidene carbene and cyclohexyne as intermediates is clearly demonstrated by trapping experiments with cyclohexene (and triethylsilane) and with 1,3- diphenylisobenzofuran, respectively. Alkynyllithiums derived from 3-butynyl and 6-heptynyl p-fluorobenzenesulfonates (19a,b) undergo a similar exo-type cyclization to give cyclopropylidene and cyclohexylidene carbenes, respectively.

LEUKOTRIENE ANTAGONISTS

This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists, processes for the preparation thereof, and pharmaceutical compositions containing such compounds.This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

Leukotriene antagonists

Leukotriene antagonist thiadiazoles have been prepared.

LEUKOTRIENE ANTAGONISTS CONTAINING TETRAZOLYL GROUPS

This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

ESTER PRODRUGS

This invention relates to ester prodrugs for alkanoic acid compounds useful as leukotriene antagonists, and pharmaceutical compositions containing such ester prodrug compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

Leukotriene antagonists

This invention relates to alkanoic acid compounds having phenyl and sulfinyl or sulfonyl substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. The invention also relates to the use of such compound for treatment of diseases in which leukotrienes are a factor.