(N_α-carbobenzyloxy-L-2-amino-3-acryloylamino)propionylglycine tert-butyl ester

Base Information

Chemical Name:(N_α-carbobenzyloxy-L-2-amino-3-acryloylamino)propionylglycine tert-butyl ester
CAS No.:366780-96-3
Molecular Formula:C₂₀H₂₇N₃O₆
Molecular Weight:405.451
Hs Code.:

(N<sub>α</sub>-carbobenzyloxy-L-2-amino-3-acryloylamino)propionylglycine tert-butyl ester

Synonyms:(N_α-carbobenzyloxy-L-2-amino-3-acryloylamino)propionylglycine tert-butyl ester

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Chemical Property of (N_α-carbobenzyloxy-L-2-amino-3-acryloylamino)propionylglycine tert-butyl ester

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Technology Process of (N_α-carbobenzyloxy-L-2-amino-3-acryloylamino)propionylglycine tert-butyl ester

There total 3 articles about (N_α-carbobenzyloxy-L-2-amino-3-acryloylamino)propionylglycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 27532-96-3
glycine tert-butyl ester hydrochloride

: 366780-92-9
N_α-carbobenzyloxy-L-2-amino-3-acryloylaminopropionic acid

: 366780-96-3
(N_α-carbobenzyloxy-L-2-amino-3-acryloylamino)propionylglycine tert-butyl ester

Guidance literature:: N_α-carbobenzyloxy-L-2-amino-3-acryloylaminopropionic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 0.25h;

glycine tert-butyl ester hydrochloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/S0968-0896(01)00292-9

Reference yield:

: 2304-96-3
N-benzyloxycarbonyl-L-asparagine

: 366780-96-3
(N_α-carbobenzyloxy-L-2-amino-3-acryloylamino)propionylglycine tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / bis(trifluoroacetoxy)phenyliodine; pyridine / dimethylformamide; H₂O / 3 h / 20 °C

2.1: 73 percent / Et₃N / methanol / 12 h / 0 - 20 °C

3.1: EDC*HCl; Et₃N / CH₂Cl₂ / 0.25 h

3.2: 70 percent / CH₂Cl₂ / 12 h / 20 °C

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00292-9

Reference yield:

: 35761-26-3
(S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid

: 366780-96-3
(N_α-carbobenzyloxy-L-2-amino-3-acryloylamino)propionylglycine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 73 percent / Et₃N / methanol / 12 h / 0 - 20 °C

2.1: EDC*HCl; Et₃N / CH₂Cl₂ / 0.25 h

2.2: 70 percent / CH₂Cl₂ / 12 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(01)00292-9