4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-chloroacetamidothiazole

Base Information

• Chemical Name: 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-chloroacetamidothiazole
• CAS No.: 94418-13-0
• Molecular Formula: C₂₆H₂₆ClN₃O₆S
• Molecular Weight: 544.028
• Mol file: 94418-13-0.mol

Synonyms:4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-chloroacetamidothiazole

Chemical Property of 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-chloroacetamidothiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-chloroacetamidothiazole

There total 3 articles about 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-chloroacetamidothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diphenylmethyl 2-Bromo-2-methylpropionate (77497-42-8) → 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-chloroacetamidothiazole (94418-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / K₂CO₃ / dimethylsulfoxide / 6 h / Ambient temperature

2: 1) 99percent formic acid / 1) 7 h, room temp., H₂O 2) 30 min., 0 deg C, dimethylacetamide 3) 1 h, room temper.

With formic acid; potassium carbonate; In dimethyl sulfoxide;

DOI:10.1002/jhet.5570210435

Reference yield:

ethyl (Z)-2-hydroxyimino-2-(2-triphenylmethylaminothiazol-4-yl)acetate (66338-99-6) → 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-chloroacetamidothiazole (94418-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / K₂CO₃ / dimethylsulfoxide / 6 h / Ambient temperature

2: 1) 99percent formic acid / 1) 7 h, room temp., H₂O 2) 30 min., 0 deg C, dimethylacetamide 3) 1 h, room temper.

With formic acid; potassium carbonate; In dimethyl sulfoxide;

DOI:10.1002/jhet.5570210435

Reference yield:

4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-tritylaminothiazole (94418-12-9) + chloroacetyl chloride (79-04-9) → 4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-chloroacetamidothiazole (94418-13-0)

Guidance literature:

With formic acid; Yield given. Multistep reaction; 1) 7 h, room temp., H₂O 2) 30 min., 0 deg C, dimethylacetamide 3) 1 h, room temper.;

DOI:10.1002/jhet.5570210435

upstream raw materials:

4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>methyl-2-tritylaminothiazole

chloroacetyl chloride

Diphenylmethyl 2-Bromo-2-methylpropionate

ethyl (Z)-2-hydroxyimino-2-(2-triphenylmethylaminothiazol-4-yl)acetate

Downstream raw materials:

4-<(Z)-1-Carbethoxy-1-(2-diphenylmethoxycarbonyl-2-propoxyimino)>-methyl-2-chloroacetamidothiazole N-Oxide