(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-hydroxyacetamide

Base Information

Chemical Name:(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-hydroxyacetamide
CAS No.:807342-13-8
Molecular Formula:C₁₅H₂₁ClN₂O₂S
Molecular Weight:328.863
Hs Code.:

Synonyms:(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-hydroxyacetamide

Suppliers and Price of (+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-hydroxyacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-hydroxyacetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-hydroxyacetamide

There total 4 articles about (+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 807342-02-5
(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]acetic acid methyl ester

: 807342-13-8
(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-hydroxyacetamide

Guidance literature:: With potassium hydroxide; hydroxylamine hydrochloride; In methanol; at 20 ℃; for 2h;
DOI:10.1021/jm040117o

Reference yield:

: 263769-24-0
(+)-4β-(4-Chlorophenyl)-3α-(hydroxymethyl)-1-methylpiperidine

: 807342-13-8
(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-hydroxyacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / PPh₃; I₂; imidazole / CH₂Cl₂ / 2.5 h / Heating

2: 88 percent / Cs₂CO₃ / acetonitrile / 20 °C

3: 76 percent / hydroxylamine hydrochloride; KOH / methanol / 2 h / 20 °C

With 1H-imidazole; potassium hydroxide; hydroxylamine hydrochloride; iodine; caesium carbonate; triphenylphosphine; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm040117o

Reference yield:

: 263769-22-8,205805-13-6
(+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate

: 807342-13-8
(+)-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-N-hydroxyacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / LiAlH₄ / tetrahydrofuran / 20 °C

2: 86 percent / PPh₃; I₂; imidazole / CH₂Cl₂ / 2.5 h / Heating

3: 88 percent / Cs₂CO₃ / acetonitrile / 20 °C

4: 76 percent / hydroxylamine hydrochloride; KOH / methanol / 2 h / 20 °C

With 1H-imidazole; potassium hydroxide; lithium aluminium tetrahydride; hydroxylamine hydrochloride; iodine; caesium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm040117o