(E)-2-(benzyloxyimino)-N-(3,5-dibromo-4-(3-(dimethylamino)propoxy)phenethyl)-3-phenylpropanamide

Base Information

Chemical Name:(E)-2-(benzyloxyimino)-N-(3,5-dibromo-4-(3-(dimethylamino)propoxy)phenethyl)-3-phenylpropanamide
CAS No.:1309665-36-8
Molecular Formula:C₂₉H₃₃Br₂N₃O₃
Molecular Weight:631.407
Hs Code.:

Synonyms:(E)-2-(benzyloxyimino)-N-(3,5-dibromo-4-(3-(dimethylamino)propoxy)phenethyl)-3-phenylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-(benzyloxyimino)-N-(3,5-dibromo-4-(3-(dimethylamino)propoxy)phenethyl)-3-phenylpropanamide

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Technology Process of (E)-2-(benzyloxyimino)-N-(3,5-dibromo-4-(3-(dimethylamino)propoxy)phenethyl)-3-phenylpropanamide

There total 4 articles about (E)-2-(benzyloxyimino)-N-(3,5-dibromo-4-(3-(dimethylamino)propoxy)phenethyl)-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 3-(4-(2-aminoethyl)-2,6-dibromophenoxy)-N,N-dimethylpropan-1-amine

: (2E)-2-[(benzyloxy)imino]-3-phenylpropanoic acid

: 1309665-36-8
(E)-2-(benzyloxyimino)-N-(3,5-dibromo-4-(3-(dimethylamino)propoxy)phenethyl)-3-phenylpropanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol303057a

Reference yield:

: 3806-42-6,174813-24-2
(Z)-5-benzylidene-2-thioxothiazolidin-4-one

: 1309665-36-8
(E)-2-(benzyloxyimino)-N-(3,5-dibromo-4-(3-(dimethylamino)propoxy)phenethyl)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water / 80 - 90 °C / Inert atmosphere

2: sodium ethanolate / ethanol / 70 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With sodium ethanolate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1021/ol303057a

Reference yield:

: 100-52-7
benzaldehyde

: 1309665-36-8
(E)-2-(benzyloxyimino)-N-(3,5-dibromo-4-(3-(dimethylamino)propoxy)phenethyl)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate / toluene / 90 - 100 °C / Inert atmosphere

2: sodium hydroxide / water / 80 - 90 °C / Inert atmosphere

3: sodium ethanolate / ethanol / 70 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With ammonium acetate; sodium ethanolate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water; toluene;
DOI:10.1021/ol303057a