4-{[(1'R,2'R)-1'-hydroxy-1',3'-dihydro-1H,2'H-2,2'-biinden-2'-yl]methyl}benzamide

Base Information

Chemical Name:4-{[(1'R,2'R)-1'-hydroxy-1',3'-dihydro-1H,2'H-2,2'-biinden-2'-yl]methyl}benzamide
CAS No.:1421332-93-5
Molecular Formula:C₂₆H₂₃NO₂
Molecular Weight:381.474
Hs Code.:

Synonyms:4-{[(1'R,2'R)-1'-hydroxy-1',3'-dihydro-1H,2'H-2,2'-biinden-2'-yl]methyl}benzamide

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Chemical Property of 4-{[(1'R,2'R)-1'-hydroxy-1',3'-dihydro-1H,2'H-2,2'-biinden-2'-yl]methyl}benzamide

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Technology Process of 4-{[(1'R,2'R)-1'-hydroxy-1',3'-dihydro-1H,2'H-2,2'-biinden-2'-yl]methyl}benzamide

There total 1 articles about 4-{[(1'R,2'R)-1'-hydroxy-1',3'-dihydro-1H,2'H-2,2'-biinden-2'-yl]methyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1380445-10-2
4-(((1R,2R)-2,3-dihydro-1-hydroxy-2-(1H-inden-2-yl)-1H-inden-2-yl)methyl)benzoic acid

: 1421332-93-5
4-{[(1'R,2'R)-1'-hydroxy-1',3'-dihydro-1H,2'H-2,2'-biinden-2'-yl]methyl}benzamide

Guidance literature:: 4-(((1R,2R)-2,3-dihydro-1-hydroxy-2-(1H-inden-2-yl)-1H-inden-2-yl)methyl)benzoic acid; With pyridine; di-tert-butyl dicarbonate; In dimethyl sulfoxide; at 20 ℃; for 0.0833333h;

With ammonium bicarbonate; In dimethyl sulfoxide; for 1h;

Reference yield:

: 35661-60-0
Fmoc-Leu-OH

: 1421332-93-5
4-{[(1'R,2'R)-1'-hydroxy-1',3'-dihydro-1H,2'H-2,2'-biinden-2'-yl]methyl}benzamide

: C₄₇H₄₄N₂O₅

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In ethyl acetate; at 20 ℃; for 12h;

Reference yield:

: 1421332-93-5
4-{[(1'R,2'R)-1'-hydroxy-1',3'-dihydro-1H,2'H-2,2'-biinden-2'-yl]methyl}benzamide

: 1421333-16-5
(1R,2R)-2-(4-carbamoylbenzyl)-2,3-dihydro-1H,1'H-2,2'-biinden-1-yl L-leucinate

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; dmap / ethyl acetate / 12 h / 20 °C

2: dimethyl amine / tetrahydrofuran / 1 h / 0 - 20 °C

With dmap; dimethyl amine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate;