Chemical Property of Fmoc-L-leucine
Chemical Property:
- Appearance/Colour:white to light yellow crystal powder
- Vapor Pressure:2.28E-13mmHg at 25°C
- Melting Point:152-156 °C(lit.)
- Refractive Index:-25 ° (C=1, DMF)
- Boiling Point:559.8 °C at 760 mmHg
- PKA:3.91±0.21(Predicted)
- Flash Point:292.4 °C
- PSA：75.63000
- Density:1.207 g/cm3
- LogP:4.41530
- Storage Temp.:2-8°C
- Solubility.:DMF (Slightly), DMSO (Slightly)
- XLogP3:4.4
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:7
- Exact Mass:353.16270821
- Heavy Atom Count:26
- Complexity:484
- Purity/Quality:
-
99%, *data from raw suppliers
NPC 15199 *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
22-24/25-36/37/39-27-26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Biological Agents -> Amino Acids and Derivatives
- Canonical SMILES:CC(C)CC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
- Isomeric SMILES:CC(C)C[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
-
Uses
Fmoc-L-Leu-OH, is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs. Fmoc-Leu-OH can be used as a reactant to synthesize:Various oligopeptides by reacting with functionalized α-amino acid hydrochloride salts.A cyclic depsipeptide sansalvamide A, a natural product found in marine fungus.Streptocidin A?D, decapeptide antibiotics naturally found in Streptomyces?sp. Tü 6071.Coumaroyl dipeptide amide that can be used for cosmetic applications.
