(3-{2-[5-(3-aminopropylcarbamoyl)-1-methyl-1H-pyrrol-3-yl-carbamoyl]-4-nitropyrrol-1-yl}-propyl)-carbamic acid tert-butyl ester

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Chemical Name:(3-{2-[5-(3-aminopropylcarbamoyl)-1-methyl-1H-pyrrol-3-yl-carbamoyl]-4-nitropyrrol-1-yl}-propyl)-carbamic acid tert-butyl ester
CAS No.:159539-43-2
Molecular Formula:C₂₄H₃₇N₇O₆
Molecular Weight:519.601
Hs Code.:

Synonyms:(3-{2-[5-(3-aminopropylcarbamoyl)-1-methyl-1H-pyrrol-3-yl-carbamoyl]-4-nitropyrrol-1-yl}-propyl)-carbamic acid tert-butyl ester

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Chemical Property of (3-{2-[5-(3-aminopropylcarbamoyl)-1-methyl-1H-pyrrol-3-yl-carbamoyl]-4-nitropyrrol-1-yl}-propyl)-carbamic acid tert-butyl ester

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Technology Process of (3-{2-[5-(3-aminopropylcarbamoyl)-1-methyl-1H-pyrrol-3-yl-carbamoyl]-4-nitropyrrol-1-yl}-propyl)-carbamic acid tert-butyl ester

There total 1 articles about (3-{2-[5-(3-aminopropylcarbamoyl)-1-methyl-1H-pyrrol-3-yl-carbamoyl]-4-nitropyrrol-1-yl}-propyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 159539-43-2
(3-{2-[5-(3-aminopropylcarbamoyl)-1-methyl-1H-pyrrol-3-yl-carbamoyl]-4-nitropyrrol-1-yl}-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide; acetone / 2 h / Inert atmosphere; Reflux

With 1H-imidazole; iodine; potassium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2013.05.126

Reference yield:

: 159539-43-2
(3-{2-[5-(3-aminopropylcarbamoyl)-1-methyl-1H-pyrrol-3-yl-carbamoyl]-4-nitropyrrol-1-yl}-propyl)-carbamic acid tert-butyl ester

: C₅₁H₆₂N₁₀O₆S

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 1.5 h / 20 °C

2: dmap; diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 13.33 h / -10 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

4: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With dmap; diethyl cyanophosphonate; palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.05.126