58885-58-8

Usage

Chemical Properties

colorless to yellow or brown liquid

InChI:InChI=1/C8H17NO3/c1-8(2,3)12-7(11)9-5-4-6-10/h10H,4-6H2,1-3H3,(H,9,11)

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 156-87-6 propan-1-ol-3-amine 
• 42116-55-2 methyl 3-tert-butoxycarbonylaminopropionate 
• 1140510-99-1 tert-butyl 2-oxoazetidine-1-carboxylate 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 34619-03-9 tert-butyldicarbonate 
• 24608-52-4 tert-butyl chloroformate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5003-71-4 3-bromopropylamine hydrochloride 
• 1034098-46-8 tert-butyl 3-(tetrahydro-2H-pyran-2-yloxy)propylcarbamate 
• 167479-01-8 tert-butyl (3-iodopropyl)carbamate 
• 1187667-17-9 tert-butyl (3-((4-methoxybenzyl)oxy)propyl)carbamate 
• 74651-77-7 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 58885-60-2 N-(tert-butoxycarbonyl)-3-aminopropanal 
• 130096-14-9 N-(tert-butoxycarbonyl)-3-aminopropyl indole-3-carboxylate 
• 83948-57-6 C₂₃H₃₀N₂O₅ 
• 83948-58-7 C₂₃H₂₉N₃O₇ 
• 83948-65-6 C₂₀H₃₂N₂O₅ 
• 83948-53-2 3-bromopropylamine tert-butylcarbamate 
• 112663-43-1 3-(tert-butoxycarbonylamino)propyl methanesulfonate 
• 181780-34-7 C₁₉H₂₅Cl₃N₂O₆ 
• 189340-39-4 2-Chlorobenzenesulfonic acid 3-[[3-N-(tert-butoxycarbonyl)amino]propoxy]-5-methylphenyl ester 
• 108998-71-6 1-tert-butyloxycarbonylaminopent-4-ene-3-ol 
• 219126-64-4 [3-(Benzothiazol-2-ylsulfanyl)-propyl]-carbamic acid tert-butyl ester 
• 243670-18-0 {3-[10-(3-tert-butoxycarbonylamino-propoxy)-8,16-dioxo-8,16-dihydro-dibenzo[a,j]perylen-2-yloxy]-propyl}-carbamic acid tert-butyl ester 
• 271785-57-0 bis[3-(tert-butoxycarbonylamino)propyl]malonate 
• 167479-01-8 tert-butyl (3-iodopropyl)carbamate 

Relevant academic research and scientific papers

Phosphine-Catalyzed Synthesis of Chiral N-Heterocycles through (Asymmetric) P(III)/P(V) Redox Cycling

Phosphine-catalyzed tandem Michael addition/intramolecular Wittig reactions have been developed for the synthesis of chiral 2,5-dihydro-1H-pyrrole and tetrahydropyridine derivatives. These processes have been rendered catalytic in phosphine, thanks to the in situ reduction of phosphine oxide by phenylsilane. Furthermore, catalytic and asymmetric P(III)/P(V) processes were implemented using enantiopure chiral phosphines.

Oxidative Deprotection of p-Methoxybenzyl Ethers via Metal-Free Photoredox Catalysis

An efficient and greener deprotection method for p-methoxybenzyl (PMB) ethers using a metal-free visible light photoredox catalyst and air and ammonium persulfate as the terminal oxidants is presented. Various functional groups and protecting groups were tolerated in the developed method to achieve good to excellent yields in short reaction times. Significantly, the developed method was compatible with PMB ethers derived from primary, secondary, and tertiary alcohols and a gram-scale reaction. Mechanistic studies support a proposed reaction mechanism that involves single electron oxidation of the PMB ether.

For the treatment of tumor macrocyclic derivatives (by machine translation)

The invention discloses a method for modulating protein kinase activity, and is used for the treatment or prevention of protein kinase related disorders. Specifically, the invention relates to a method for the treatment of tumor of the macrocyclic derivatives, which belongs to the regulating Anaplastic lymphoma kinase (ALK) active compound, and provides the preparation method of the compound, and the compound used for the treatment or prevention of diseases associated with the ALK pharmaceutical use. (by machine translation)

Ligand-controlled α- And β-arylation of acyclic N-boc amines

The palladium-catalyzed ligand-controlled arylation of α-zincated acyclic amines, obtained by directed α-lithiation and transmetalation, is described. Whereas PtBu3 gave rise to α-arylated Boc-protected amines, more flexible N-phenylazole-based phosphine ligands induced major β-arylation through migrative cross-coupling. All manner of control: The arylation of α-zincated acyclic Boc-protected amines was selectively performed at the α- or β-position in a ligand-controlled manner. α-Arylation occurs by direct reductive elimination of the α-palladated intermediate whereas β-arylation involves palladium migration along the alkyl chain. Boc=tert-butoxycarbonyl.

INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING ALPHA-V-BETA-3

The invention relates to compounds of formula (I): wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula (I) for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to alpha-V-beta-3 integrin antagonists to target cells expressing alpha-V-beta-3.

Zinc triflate: A mild and efficient catalyst for deprotection of tetrahydropyranyl ethers

Treatment of tetrahydropyranyl (THP) ethers with zinc triflate in methanol provides a simple and efficient process for deprotection of these ethers and the parent alcohols are obtained in excellent yields.

Simple and efficient method for deprotection of tetrahydropyranyl ethers by using Silica supported sodium hydrogen sulphate

Tetrahydropyranyl (THP) ethers have been efficiently and simply deprotected by using Silica supported sodium hydrogen sulphate (NaHSO4-SiO 2) in methanol at room temperature to regenerate the parent alcohols in high yields. Tetrahydropyranyl (THP) ethers have been efficiently and simply deprotected by using silica supported sodium hydrogen sulphate (NaHSO 4-SiO2) in methanol at room temperature to regenerate the parent alcohols in high yields.

Oxidative photoredox catalysis: Mild and selective deprotection of PMB ethers mediated by visible light

Herein we report an advancement in the application of visible light photoredox catalysts in the oxidation of electron-rich arenes resulting in the selective deprotection of para-methoxybenzyl (PMB) ethers. This method is highlighted by excellent functional group tolerance, protecting group orthogonality, mild reaction conditions and avoidance of stoichiometric redox byproducts.

Hydrogenation of N-acylcarbamates and N-acylsulfonamides catalyzed by a bifunctional [Cp*Ru(PN)] complex

Awakening of the Cp one: the bifunctional complex 1 facilitates the interaction with substrates bearing less electrophilic carbon atoms than ketones, epoxides, and imides. The title reaction was applicable to the reduction of Evans' asymmetric alkylation products to the chiral alcohols along with gtood recovery of the chiral oxazolidinone auxiliary. EWG=electron- withdrawing group.

Preliminary biological evaluations of new thalidomide analogues for multiple sclerosis application

The present work deals with the synthesis of a new series of thalidomide derivatives for therapeutic applications. These compounds were evaluated in vitro on a human endothelial cell line EA.hy926 for their antiproliferative potential and in vivo on an experimental animal multiple sclerosis model called EAE as angiogenesis inhibitors. The preliminary results obtained on EAE assays seem to validate that anti-angiogenesis compounds could be promising tools for the treatment of MS.