58885-58-8

Basic information

• Product Name: 3-(BOC-AMINO)-1-PROPANOL
• Synonyms: TERT-BUTYL (3-HYDROXYPROPYL)CARBAMATE;TERT-BUTYL N-(3-HYDROXYPROPYL)CARBAMATE;N-(3-HYDROXYPROPYL)CARBAMIC ACID TERT-BUTYL ESTER;N-T-BUTOXYCARBONYL-3-AMINO-1-PROPANOL;N-T-BUTOXYCARBONYL-BETA-ALANINOL;CARBAMIC ACID,(3-HYDROXYPROPYL)-, 1,1-DIMETHYLETHYL ESTER;BOC-NH-(CH2)3-OH;BOC-3-AMINO-1-PROPANOL
• CAS NO: 58885-58-8
• Molecular Formula: C₈H₁₇NO₃
• Molecular Weight: 175.23
• Mol File: 58885-58-8.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 293℃
• Flash Point: >230 °F
• Appearance: colorless to yellow or brown liquid
• Density: 1.025 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.000194mmHg at 25°C
• Refractive Index: n20/D 1.453
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.57±0.46(Predicted)
• BRN: 1860807
• CAS DataBase Reference: 3-(BOC-AMINO)-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(BOC-AMINO)-1-PROPANOL(58885-58-8)
• EPA Substance Registry System: 3-(BOC-AMINO)-1-PROPANOL(58885-58-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 23-24/25-37/39-26
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 58885-58-8(Hazardous Substances Data)

Usage

Chemical Properties

colorless to yellow or brown liquid

InChI:InChI=1/C8H17NO3/c1-8(2,3)12-7(11)9-5-4-6-10/h10H,4-6H2,1-3H3,(H,9,11)

Upstream product

• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 
• 1140510-99-1 tert-butyl 2-oxoazetidine-1-carboxylate 
• 1034098-46-8 tert-butyl 3-(tetrahydro-2H-pyran-2-yloxy)propylcarbamate 
• 34619-03-9 tert-butyldicarbonate 
• 156-87-6 propan-1-ol-3-amine 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 24608-52-4 tert-butyl chloroformate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5003-71-4 3-bromopropylamine hydrochloride 
• 167479-01-8 tert-butyl (3-iodopropyl)carbamate 
• 1187667-17-9 tert-butyl (3-((4-methoxybenzyl)oxy)propyl)carbamate 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 74651-77-7 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 58885-60-2 N-(tert-butoxycarbonyl)-3-aminopropanal 
• 114326-12-4 [3-(tert-butyldimethylsilanyloxy)propyl]carbamic acid tert-butyl ester 
• 181943-72-6 (1R,5S,7R)-3-Ethyl-2-oxo-6,8-dioxa-3-aza-bicyclo[3.2.1]octane-7-carboxylic acid (R)-12-acetoxy-2-acetyl-5-(3-tert-butoxycarbonylamino-propoxymethyl)-1,2,3,4-tetrahydro-naphthacen-2-yl ester 
• 243670-18-0 {3-[10-(3-tert-butoxycarbonylamino-propoxy)-8,16-dioxo-8,16-dihydro-dibenzo[a,j]perylen-2-yloxy]-propyl}-carbamic acid tert-butyl ester 
• 271785-57-0 bis[3-(tert-butoxycarbonylamino)propyl]malonate 
• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 
• 623562-63-0 [3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester 
• 912816-63-8 4-[3-N-(tert-butyloxycarbonyl)propyloxy]-5-methoxybenzaldehyde 
• 1016641-65-8 C₂₄H₂₄N₄O₆ 
• 889107-93-1 methyl 2-(3-tert-butoxycarbonylaminopropoxy)-4-tert-butylbenzoate 
• 69038-04-6 N-hydroxysuccinimide ester of 4-(tert-butoxycarbonylamino)butyric acid 
• 1026119-17-4 (NHC₃H₄⁽²⁾H₂NH₂)2C₄H₈COCH₂(CO₂C₄H₈)2 
• 1026119-11-8 N-Boc-spermidine-ol 
• 134935-52-7 (4-hydroxybutyl)<<3-(1,1-dimethylethoxy)carbonylamino>propyl>carbamic acid, 1,1-dimethylethyl ester 

Relevant articles and documents

Phosphine-Catalyzed Synthesis of Chiral N-Heterocycles through (Asymmetric) P(III)/P(V) Redox Cycling

Phosphine-catalyzed tandem Michael addition/intramolecular Wittig reactions have been developed for the synthesis of chiral 2,5-dihydro-1H-pyrrole and tetrahydropyridine derivatives. These processes have been rendered catalytic in phosphine, thanks to the in situ reduction of phosphine oxide by phenylsilane. Furthermore, catalytic and asymmetric P(III)/P(V) processes were implemented using enantiopure chiral phosphines.

For the treatment of tumor macrocyclic derivatives (by machine translation)

The invention discloses a method for modulating protein kinase activity, and is used for the treatment or prevention of protein kinase related disorders. Specifically, the invention relates to a method for the treatment of tumor of the macrocyclic derivatives, which belongs to the regulating Anaplastic lymphoma kinase (ALK) active compound, and provides the preparation method of the compound, and the compound used for the treatment or prevention of diseases associated with the ALK pharmaceutical use. (by machine translation)

INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING ALPHA-V-BETA-3

The invention relates to compounds of formula (I): wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula (I) for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to alpha-V-beta-3 integrin antagonists to target cells expressing alpha-V-beta-3.