4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexylamine

Base Information

Chemical Name:4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexylamine
CAS No.:946605-81-8
Molecular Formula:C₁₉H₂₇F₃N₂O
Molecular Weight:356.431
Hs Code.:

Synonyms:4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexylamine

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Chemical Property of 4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexylamine

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Technology Process of 4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexylamine

There total 8 articles about 4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910605-45-7
(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-carbamic acid tert-butyl ester

: 946605-81-8
4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexylamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2007.04.098 DOI:10.1016/j.bmcl.2007.09.051

Reference yield:

: 218610-57-2
1-bromo-2-(2,2,2-trifluoroethoxy)benzene

: 946605-81-8
4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: nBuLi / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran

2.1: 50 percent / MsCl; Et₃N / CH₂Cl₂ / 12 h / -78 °C

3.1: 80 percent / H₂ / Pd/C / 8 h / 20 °C / 2327.23 Torr

4.1: 100 percent / TFA / CH₂Cl₂ / 3 h / 0 °C

5.1: NaBH(OAc)3; AcOH / CH₂Cl₂ / 8 h / 20 °C

6.1: CF₃CO₂H / CH₂Cl₂ / 2 h / 20 °C

With n-butyllithium; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2007.04.098

Reference yield:

: 946605-58-9
C₁₈H₂₄F₃NO₄

: 946605-81-8
4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / MsCl; Et₃N / CH₂Cl₂ / 12 h / -78 °C

2: 80 percent / H₂ / Pd/C / 8 h / 20 °C / 2327.23 Torr

3: 100 percent / TFA / CH₂Cl₂ / 3 h / 0 °C

4: NaBH(OAc)3; AcOH / CH₂Cl₂ / 8 h / 20 °C

5: CF₃CO₂H / CH₂Cl₂ / 2 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/j.bmcl.2007.04.098