218610-57-2

Basic information

• Product Name: 1-bromo-2-(2,2,2-trifluoroethoxy)benzene
• Synonyms: 1-bromo-2-(2,2,2-trifluoroethoxy)benzene;2-(2,2,2-Trifluoroethoxy)bromobenzene
• CAS NO: 218610-57-2
• Molecular Formula: C₈H₆BrF₃O
• Molecular Weight: 255.0318496
• Mol File: 218610-57-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 1-bromo-2-(2,2,2-trifluoroethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-(2,2,2-trifluoroethoxy)benzene(218610-57-2)
• EPA Substance Registry System: 1-bromo-2-(2,2,2-trifluoroethoxy)benzene(218610-57-2)

Safety Data

• Hazardous Substances Data: 218610-57-2(Hazardous Substances Data)

Usage

Description

1-bromo-2-(2,2,2-trifluoroethoxy)benzene is a chemical compound with the molecular formula C8H6BrF3O. It is a colorless liquid with a molecular weight of 251.03 g/mol. 1-bromo-2-(2,2,2-trifluoroethoxy)benzene is characterized by the presence of a bromine atom and a trifluoroethoxy group, which contribute to its reactivity and versatility in organic synthesis.

Uses

Used in Organic Synthesis:
1-bromo-2-(2,2,2-trifluoroethoxy)benzene is used as a reagent in various chemical reactions for the synthesis of other organic compounds. Its reactivity, due to the bromine atom, allows it to participate in a wide range of organic reactions, making it a valuable compound in the field of organic chemistry.
Used in Pharmaceutical Production:
1-bromo-2-(2,2,2-trifluoroethoxy)benzene serves as an intermediate in the production of pharmaceuticals. Its unique structure and reactivity enable the synthesis of various drug molecules, contributing to the development of new medications and therapies.
Used in Agrochemical Production:
In addition to pharmaceuticals, 1-bromo-2-(2,2,2-trifluoroethoxy)benzene is also utilized as an intermediate in the production of agrochemicals. Its applications in this industry help in the development of effective pesticides, herbicides, and other agricultural chemicals to improve crop yields and protect plants from pests and diseases.

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 1072-85-1 o-fluorobromobenzene 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 95-56-7 2-hydroxybromobenzene 

Downstream Products

• 957060-90-1 (2-(2,2,2-trifluoroethoxy)phenyl)boronic acid 
• 864754-11-0 4,4,5,5-tetramethyl-2-(2-(2,2,2-trifluoroethoxy)phenyl)-1,3,2-dioxaborolane 
• 790643-36-6 (4S)-4-(3,4-Difluorophenyl)-6-methoxymethyl-2-oxo-3-(2-(1-(2-(2,2,2-trifluoroethoxy)phenyl)piperidin-4-ylamino)ethylcarbamoyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester 
• 218610-61-8 (2-(1-(2-(2,2,2-Trifluoroethoxy)phenyl)piperidin-4-ylamino)ethyl)-carbamic acid tert-butyl ester 
• 218610-62-9 N₁-(1-(2-(2,2,2-Trifluoroethoxy)phenyl)piperidin-4-yl)ethane-1,2-diamine 
• 218610-59-4 N-(o-(2,2,2-Trifluoroethoxy)phenyl)-4-piperidone 
• 1426801-83-3 C₂₄H₂₁ClF₃NO₄S 
• 910605-42-4 3,4-dimethoxy-N-trans-(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-benzenesulfonamide 
• 910605-41-3 3,4-dimethoxy-N-cis-(4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-benzenesulfonamide 
• 946605-81-8 4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexylamine 
• 910605-45-7 (4-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidin-1-yl}-cyclohexyl)-carbamic acid tert-butyl ester 
• 946605-74-9 4-[4-(2-cyclopropoxy-phenyl)-piperidin-1-yl]-cyclohexylamine 
• 910605-44-6 4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

(2, 2, 2 - trifluoroethoxy) phenyl boronic acid synthetic method of compound (by machine translation)

The invention discloses a (2, 2, 2 - trifluoroethoxy) phenyl boronic acid compound synthesis method. In order to O bromine monofluoro-benzene and its derivative as the starting material, in the alkaline conditions and trifluoro ethanol produced by the reaction of 1 - bromo - 2 - (2, 2, 2 - trifluoroethoxy) benzene and its derivatives, to obtain the product of the metal reagent under the action of the borate reaction to obtain the type III compound 2 - (2, 2, 2 - trifluoroethoxy) phenyl boronic acid and its derivatives. The synthesis route is relatively short, low cost, easy to operate, the yield is high. Can be used for the production of industrial expansion. (by machine translation)

BIARYL SUBSTITUTED TRIAZOLES AS SODIUM CHANNEL BLOCKERS

Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant com