tert-butyl 3-({(6′R,7′R,8a′R)-10-(4′′-methoxybenzyl)-5′,9′-dioxo-7′-(prop-1′′′-en-2′′′-yl)hexahydro-1H-6′,8a′-(epiminomethano)indolizin-6′-yl}methyl)-1H-indole-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-({(6′R,7′R,8a′R)-10-(4′′-methoxybenzyl)-5′,9′-dioxo-7′-(prop-1′′′-en-2′′′-yl)hexahydro-1H-6′,8a′-(epiminomethano)indolizin-6′-yl}methyl)-1H-indole-1-carboxylate
CAS No.:116005-49-3
Molecular Formula:C₃₄H₃₉N₃O₅
Molecular Weight:569.701
Hs Code.:

tert-butyl 3-({(6′R,7′R,8a′R)-10-(4′′-methoxybenzyl)-5′,9′-dioxo-7′-(prop-1′′′-en-2′′′-yl)hexahydro-1H-6′,8a′-(epiminomethano)indolizin-6′-yl}methyl)-1H-indole-1-carboxylate

Synonyms:tert-butyl 3-({(6′R,7′R,8a′R)-10-(4′′-methoxybenzyl)-5′,9′-dioxo-7′-(prop-1′′′-en-2′′′-yl)hexahydro-1H-6′,8a′-(epiminomethano)indolizin-6′-yl}methyl)-1H-indole-1-carboxylate

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Chemical Property of tert-butyl 3-({(6′R,7′R,8a′R)-10-(4′′-methoxybenzyl)-5′,9′-dioxo-7′-(prop-1′′′-en-2′′′-yl)hexahydro-1H-6′,8a′-(epiminomethano)indolizin-6′-yl}methyl)-1H-indole-1-carboxylate

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Technology Process of tert-butyl 3-({(6′R,7′R,8a′R)-10-(4′′-methoxybenzyl)-5′,9′-dioxo-7′-(prop-1′′′-en-2′′′-yl)hexahydro-1H-6′,8a′-(epiminomethano)indolizin-6′-yl}methyl)-1H-indole-1-carboxylate

There total 18 articles about tert-butyl 3-({(6′R,7′R,8a′R)-10-(4′′-methoxybenzyl)-5′,9′-dioxo-7′-(prop-1′′′-en-2′′′-yl)hexahydro-1H-6′,8a′-(epiminomethano)indolizin-6′-yl}methyl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1024013-31-7
C₃₄H₄₁N₃O₅

: 116005-49-3
tert-butyl 3-({(6′R,7′R,8a′R)-10-(4′′-methoxybenzyl)-5′,9′-dioxo-7′-(prop-1′′′-en-2′′′-yl)hexahydro-1H-6′,8a′-(epiminomethano)indolizin-6′-yl}methyl)-1H-indole-1-carboxylate

Guidance literature:: With copper dichloride; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1039/c3ob40979a

Reference yield: 41.0%

: 905980-66-7
7-(1-tert-butoxycarbonyl-1H-indol-3-ylmethyl)-8-(4-methoxy-benzyl)-6,9-dioxo-5,8-diaza-tricyclo[5.2.2.0^1,5]undecane-11-carboxylic acid methyl ester

: 75-16-1
methylmagnesium bromide

: 3-[(1R,7R,11S)-11-Acetyl-8-(4-methoxy-benzyl)-6,9-dioxo-5,8-diaza-tricyclo[5.2.2.0^1,5]undec-7-ylmethyl]-indole-1-carboxylic acid tert-butyl ester

: 116005-49-3
1-(R)-<methyl>-2,8-diketo-10-(S)-(1-methylethenyl)-9-(4-methoxybenzyl)-3,9-diazatricyclo<5.2.2.0^3,7>undecane

Guidance literature:: 7-(1-tert-butoxycarbonyl-1H-indol-3-ylmethyl)-8-(4-methoxy-benzyl)-6,9-dioxo-5,8-diaza-tricyclo[5.2.2.0^1,5]undecane-11-carboxylic acid methyl ester; methylmagnesium bromide; In tetrahydrofuran; toluene; at 0 ℃; for 2h;

With Burgess Reagent; In benzene; at 50 ℃; for 0.333333h;
DOI:10.1021/ja061660s