1-(4-(4-(3-chloropropoxy)phenyl)-4-(4-(3-iodopropoxy)phenyl)piperidin-1-yl)ethanone

Base Information

• Chemical Name: 1-(4-(4-(3-chloropropoxy)phenyl)-4-(4-(3-iodopropoxy)phenyl)piperidin-1-yl)ethanone
• CAS No.: 1425732-57-5
• Molecular Formula: C₂₅H₃₁ClINO₃
• Molecular Weight: 555.884

Synonyms:1-(4-(4-(3-chloropropoxy)phenyl)-4-(4-(3-iodopropoxy)phenyl)piperidin-1-yl)ethanone

Chemical Property of 1-(4-(4-(3-chloropropoxy)phenyl)-4-(4-(3-iodopropoxy)phenyl)piperidin-1-yl)ethanone

Chemical Property:

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Technology Process of 1-(4-(4-(3-chloropropoxy)phenyl)-4-(4-(3-iodopropoxy)phenyl)piperidin-1-yl)ethanone

There total 6 articles about 1-(4-(4-(3-chloropropoxy)phenyl)-4-(4-(3-iodopropoxy)phenyl)piperidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-hydroxy-4-(4-methoxyphenyl)piperidin-1-yl)ethanone (158984-57-7) → 1-(4-(4-(3-chloropropoxy)phenyl)-4-(4-(3-iodopropoxy)phenyl)piperidin-1-yl)ethanone (1425732-57-5)

Guidance literature:

Multi-step reaction with 4 steps

1: boron tribromide / dichloromethane / 3 h / Inert atmosphere; Reflux

2: potassium carbonate / acetonitrile / 26 h / Reflux

3: boron trifluoride diethyl etherate / dichloromethane / 23 h / 20 °C / Schlenk technique

4: potassium carbonate; 2,6-di-tert-butyl-4-methyl-phenol / acetone / 5 h / Reflux

With 2,6-di-tert-butyl-4-methyl-phenol; boron trifluoride diethyl etherate; boron tribromide; potassium carbonate; In dichloromethane; acetone; acetonitrile;

DOI:10.1002/chem.201202498

Reference yield:

1-acetyl-4-piperidinone (32161-06-1) → 1-(4-(4-(3-chloropropoxy)phenyl)-4-(4-(3-iodopropoxy)phenyl)piperidin-1-yl)ethanone (1425732-57-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: magnesium / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux

1.2: 4 h / 0 - 20 °C / Inert atmosphere

1.3: 17 h / 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 3 h / Inert atmosphere; Reflux

3.1: potassium carbonate / acetonitrile / 26 h / Reflux

4.1: boron trifluoride diethyl etherate / dichloromethane / 23 h / 20 °C / Schlenk technique

5.1: potassium carbonate; 2,6-di-tert-butyl-4-methyl-phenol / acetone / 5 h / Reflux

With 2,6-di-tert-butyl-4-methyl-phenol; boron trifluoride diethyl etherate; boron tribromide; potassium carbonate; magnesium; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;

DOI:10.1002/chem.201202498

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → 1-(4-(4-(3-chloropropoxy)phenyl)-4-(4-(3-iodopropoxy)phenyl)piperidin-1-yl)ethanone (1425732-57-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: magnesium / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux

1.2: 4 h / 0 - 20 °C / Inert atmosphere

1.3: 17 h / 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 3 h / Inert atmosphere; Reflux

3.1: potassium carbonate / acetonitrile / 26 h / Reflux

4.1: boron trifluoride diethyl etherate / dichloromethane / 23 h / 20 °C / Schlenk technique

5.1: potassium carbonate; 2,6-di-tert-butyl-4-methyl-phenol / acetone / 5 h / Reflux

With 2,6-di-tert-butyl-4-methyl-phenol; boron trifluoride diethyl etherate; boron tribromide; potassium carbonate; magnesium; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;

DOI:10.1002/chem.201202498

upstream raw materials:

1-bromo-4-methoxy-benzene

1-acetyl-4-piperidinone

1-(4-hydroxy-4-(4-methoxyphenyl)piperidin-1-yl)ethanone

1,3-Diiodopropane

Downstream raw materials:

1-(4-(4-(3-(4-(1-acetyl-4-(4-((2-nitrobenzyl)oxy)phenyl)piperidin-4-yl)-3-methoxyphenoxy)propoxy)phenyl)-4-(4-(3-chloropropoxy)phenyl)piperidin-1-yl)ethanone

1-(4-(4-(3-(4-(1-acetyl-4-(4-(3-chloropropoxy)phenyl)piperidin-4-yl)phenoxy)propoxy)-2-methoxyphenyl)-4-(4-hydroxyphenyl)piperidin-1-yl)ethanone

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