5'-Dimethoxytrityl-2'-deoxyuridine-5-<2-(N'-(trifluoroacetyl)amino)ethyl>propionamide-3'-(O-methyl(diisopropylamino))phosphoramidate

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Chemical Name:5'-Dimethoxytrityl-2'-deoxyuridine-5-<2-(N'-(trifluoroacetyl)amino)ethyl>propionamide-3'-(O-methyl(diisopropylamino))phosphoramidate
CAS No.:121329-88-2
Molecular Formula:C₄₄H₅₅F₃N₅O₁₀P
Molecular Weight:901.917
Hs Code.:

Synonyms:5'-Dimethoxytrityl-2'-deoxyuridine-5-<2-(N'-(trifluoroacetyl)amino)ethyl>propionamide-3'-(O-methyl(diisopropylamino))phosphoramidate

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Chemical Property of 5'-Dimethoxytrityl-2'-deoxyuridine-5-<2-(N'-(trifluoroacetyl)amino)ethyl>propionamide-3'-(O-methyl(diisopropylamino))phosphoramidate

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Technology Process of 5'-Dimethoxytrityl-2'-deoxyuridine-5-<2-(N'-(trifluoroacetyl)amino)ethyl>propionamide-3'-(O-methyl(diisopropylamino))phosphoramidate

There total 2 articles about 5'-Dimethoxytrityl-2'-deoxyuridine-5-<2-(N'-(trifluoroacetyl)amino)ethyl>propionamide-3'-(O-methyl(diisopropylamino))phosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 86030-43-5
N,N-diisopropylmethylphosphonamidic chloride

: 121329-87-1
5’-O-(4,4’-dimethoxytrityl)-5-[2-(trifluoroacetylamino)ethylaminocarbonylethyl]-2’-deoxyuridine

: 121329-88-2
5'-Dimethoxytrityl-2'-deoxyuridine-5-<2-(N'-(trifluoroacetyl)amino)ethyl>propionamide-3'-(O-methyl(diisopropylamino))phosphoramidate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;
DOI:10.1021/ja00200a011

Reference yield:

: 96203-41-7
5'-O-DMT-5-<3-<(2-aminoethyl)-amino>-3-oxopropyl>-2'-deoxyuridine

: 121329-88-2
5'-Dimethoxytrityl-2'-deoxyuridine-5-<2-(N'-(trifluoroacetyl)amino)ethyl>propionamide-3'-(O-methyl(diisopropylamino))phosphoramidate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / triethylamine / methanol / 16 h / Ambient temperature

2: 85 percent / diisopropylethylamine / CH₂Cl₂ / 1 h

With triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/ja00200a011