121329-87-1Relevant academic research and scientific papers
Studies on the two thymine residues in the catalytic core of 10-23 DNAzyme: The impact on the catalysis of their 5-substituted functional groups
Li, Pengyu,Du, Shanshan,Li, Yang,He, Junlin
, (2017/06/30)
In the 15-mer catalytic core of 10-23 DNAzyme, each residue contributes to the catalytic conformation differently. Here, the critically conserved T4 and the least conserved T8 were modified on their 5-position with hydroxyl, imidazolyl, and amino groups with a hydrogen-bonding ability. These external functional groups induced new interactions within the catalytic core, resulting in both negative and positive effects on the catalytic activity of 10-23 DNAzyme, and the different linkages could be used to modulate the effect of the functional groups. The conservation of T4 and T8 could be recognized at the level of the nucleobase, but at the level of the functional group, T4 is not completely conserved. Their 5-methyl groups could be modified for a better performance in terms of the DNAzyme.
Nucleoside compound or salt thereof, nucleic acid and application of nucleic acid
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Paragraph 0243; 0246; 0258; 0259; 0260; 0261; 0262, (2017/10/22)
The invention belongs to the field of biological medicine and relates to a nucleoside compound or salt thereof as shown in formula I, nucleic acid based on the nucleoside compound or salt and application of the nucleic acid. The nucleic acid can be used a
Synthesis and Characterization of DNA Oligomers and Duplexes Containing Covalently Attached Molecular Labels: Comparison of Biotin, Fluorescein, and Pyrene Labels by Thermodynamic and Optical Spectroscopic Measurements
Telser, Joshua,Cruickshank, Kenneth A.,Morrison, Larry E.,Netzel, Thomas L.
, p. 6966 - 6976 (2007/10/02)
A series of oligonucleotides having the base sequence 5'-GCA(C*-L)(T*-L)CAG-3' have been synthesized where C* and T* respectively a chemically modified cytidine or thymidine base containing a linker arm terminat
