(1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol

Base Information

Chemical Name:(1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol
CAS No.:141271-13-8
Molecular Formula:C₁₆H₁₆Cl₂N₆O
Molecular Weight:379.249
Hs Code.:

Synonyms:(1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol

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Chemical Property of (1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol

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Technology Process of (1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol

There total 7 articles about (1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 106-47-8
4-chloro-aniline

: 141271-11-6
(-)-(1S,4R)-4-<(2'-amino-6'-chloropyrimidin-4'-yl)amino>-cyclopent-2-enylmethanol

: 141271-13-8
(1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol

Guidance literature:: 4-chloro-aniline; With hydrogenchloride; sodium nitrite; In water; at 10 ℃;

(-)-(1S,4R)-4-<(2'-amino-6'-chloropyrimidin-4'-yl)amino>-cyclopent-2-enylmethanol; With sodium acetate; In water; acetic acid; at 20 ℃; for 18h;

Reference yield:

: 130931-86-1
(-)-(1S,4R)-4-acetamidocyclopent-2-enylmethanol

: 141271-13-8
(1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 2 M hydrochloric acid / ethanol / 48 h / Heating

2: diisopropylethylamine / butan-1-ol / 14 h / Heating

3: 1.) sodium nitrite, 2.7 M hydrochloric acid 2.) sodium acetate, glacial acetic acid / 1.) water, 9 deg C 2.) water, room temp., 27 h

With hydrogenchloride; sodium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In ethanol; butan-1-ol;

Reference yield:

: 127061-46-5
methyl (+)-cis-4-acetamidocyclopent-2-enecarboxylate

: 141271-13-8
(1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / calcium chloride, sodium borohydride / tetrahydrofuran / 3 h / 40 °C / sonication

2: 2 M hydrochloric acid / ethanol / 48 h / Heating

3: diisopropylethylamine / butan-1-ol / 14 h / Heating

4: 1.) sodium nitrite, 2.7 M hydrochloric acid 2.) sodium acetate, glacial acetic acid / 1.) water, 9 deg C 2.) water, room temp., 27 h

With hydrogenchloride; sodium tetrahydroborate; sodium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; calcium chloride; sodium nitrite; In tetrahydrofuran; ethanol; butan-1-ol;