127061-46-5

Basic information

• Product Name: ester methylique de l'acide (acetamido-cis-4)-cyclopentene-2-carboxylique
• CAS NO: 127061-46-5
• Molecular Weight: 183.207
• Mol File: 127061-46-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ester methylique de l'acide (acetamido-cis-4)-cyclopentene-2-carboxylique(CAS DataBase Reference)
• NIST Chemistry Reference: ester methylique de l'acide (acetamido-cis-4)-cyclopentene-2-carboxylique(127061-46-5)
• EPA Substance Registry System: ester methylique de l'acide (acetamido-cis-4)-cyclopentene-2-carboxylique(127061-46-5)

Safety Data

• Hazardous Substances Data: 127061-46-5(Hazardous Substances Data)

Upstream product

• 49805-30-3 racemic 2-azabicyclo[2.2.1]hept-5-en-3-one 
• 49805-30-3 2-azabicyclo[2.2.1.]hept-5-en-3-one 
• 102579-71-5 cis-4-amino-cyclopent-2-ene-1-carboxylic acid 
• 121-46-0 bicyclo[2.2.1]hepta-2,5-diene 
• 30213-23-1 meso-cyclopent-4-ene-1,3-dicarboxylic acid 
• 67-56-1 methanol 
• 108-24-7 acetic anhydride 
• 77745-25-6 cis-4-amino-2-cyclopentenecarboxylic acid methyl ester hydrochloride 
• 152279-17-9 (cis)-methyl 4-aminocyclopent-2-enecarboxylate 
• 546-67-8 lead(IV) tetraacetate 

Downstream Products

• 172721-00-5 (+/-)-trans-4-(2-amino-6-chloro-9-H-purin-9-yl)-2-cyclopentene-1-methanol 
• 50619-37-9 (-)-(1R,2S,3R,4R)-4-amino-2,3-dihydroxy-1-hydroxymethyl cyclopentane 
• 13190-81-3 N-((1R,3S,4R)-2,3-Dihydroxy-4-hydroxymethyl-cyclopentyl)-acetamide 
• 13190-81-3 N-((1S,3R,4S)-2,3-Dihydroxy-4-hydroxymethyl-cyclopentyl)-acetamide 
• 50619-37-9 (+)-(1S,2R,3S,4S)-4-amino-2,3-dihydroxy-1-hydroxymethyl cyclopentane 
• 141352-48-9 (1S,4R)-4-(benzyloxycarbonylamino)-2-cyclopentene-1-methanol 
• 102579-71-5 (-)-(1S, 4R)-4-amino-2-cyclopentene-1-carboxylic acid 
• 141352-47-8 (1S,4R)-4-(benzyloxycarbonylamino)-2-cyclopentene-1-carboxylic acid methyl ester 
• 136522-33-3 (1S,4R)-4-[2-amino-6-chloro-9H-purin-9-yl]-2-cyclopentene-1-methanol 
• 141271-13-8 (1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol 
• 141271-12-7 (1S, 4R)-(4-(2,5-diamino-6-chloro-4-pyrimidinyl)amino)-2-cyclopenten-1-methanol 
• 141271-11-6 (-)-(1S,4R)-4-<(2'-amino-6'-chloropyrimidin-4'-yl)amino>-cyclopent-2-enylmethanol 
• 136522-35-5 (1R,4S)-1-amino-4-hydroxymethyl-2-cyclopentene 
• 106707-52-2 (1β,2β,3α,5α)-5-Amino-3-hydroxymethyl-1,2-cyclopentanediol 

Relevant articles and documents

Substituent and solvent effects in the 1,3-dipolar cycloadditions for synthesis of anti-influenza agent peramivir and its analog

Influenza remains a health problem to humans. Peramivir is a FDA approved anti-influenza drug targeting the virus neuraminidase. The (3 + 2) cycloaddition reaction of 2-ethylbutanenitrile oxide with the cyclopentene dipolarophile derived from Vince lactam is a key step in the conventional synthesis of peramivir. Our study showed that conducting the (3 + 2) cycloaddition reactions with either aliphatic or aromatic nitrile oxide in hexane solution provided high percentage of the desired regioisomer, and the N-substituent having electron-withdrawing property is also beneficial to the regioselectivity. This study also demonstrated an alternative synthetic pathway of (?)-peramivir and the analog having a phenyl group in place of the 3-pentyl moiety.

Biocatalytical Transformations. IV. Enantioselective Enzymatic Hydrolyses of Building Blocks for the Synthesis of Carbocyclic Nucleosides

Enantiomerically pure alkyl (1S,4R)- and (1R,4S)-4-acetamido-cyclopent-2-ene-carboxylates are obtained from their corresponding racemates by hydrolysis with PLE or the lipase from Candida cylindracea.

Synthesis of carbocyclic aminonucleosides

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