5,5'-dimethoxy-N,N'-dimethyl-6,6'-bis(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethoxy)biphenyl-2,2'-dicarboxamide

Base Information

Chemical Name:5,5'-dimethoxy-N,N'-dimethyl-6,6'-bis(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethoxy)biphenyl-2,2'-dicarboxamide
CAS No.:1326579-33-2
Molecular Formula:C₃₆H₃₂F₆N₄O₈
Molecular Weight:762.662
Hs Code.:

Synonyms:5,5'-dimethoxy-N,N'-dimethyl-6,6'-bis(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethoxy)biphenyl-2,2'-dicarboxamide

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Chemical Property of 5,5'-dimethoxy-N,N'-dimethyl-6,6'-bis(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethoxy)biphenyl-2,2'-dicarboxamide

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Technology Process of 5,5'-dimethoxy-N,N'-dimethyl-6,6'-bis(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethoxy)biphenyl-2,2'-dicarboxamide

There total 7 articles about 5,5'-dimethoxy-N,N'-dimethyl-6,6'-bis(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethoxy)biphenyl-2,2'-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1233979-42-4
6,6'-dihydroxy-5,5'-dimethoxy-N,N'-dimethylbiphenyl-2,2'-dicarboxamide

: 1326579-33-2
5,5'-dimethoxy-N,N'-dimethyl-6,6'-bis(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethoxy)biphenyl-2,2'-dicarboxamide

Guidance literature:: 6,6'-dihydroxy-5,5'-dimethoxy-N,N'-dimethylbiphenyl-2,2'-dicarboxamide; With potassium carbonate; In ethanol; at 20 ℃; for 0.5h;

2-halo-N-(3-trifluoromethylphenyl)acetamide; In ethanol; for 10h; Reflux;
DOI:10.2174/157340611796150914

Reference yield:

: 621-59-0
isovanillin

: 1326579-33-2
5,5'-dimethoxy-N,N'-dimethyl-6,6'-bis(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethoxy)biphenyl-2,2'-dicarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium acetate; iron / acetic acid / 0.5 h / 20 °C

1.2: 3 h / 23 - 25 °C

2.1: potassium carbonate / ethanol / 4 h / Reflux

3.1: sodium dihydrogenphosphate / tetrahydrofuran; water / 0.17 h / 20 °C

3.2: 3 h / 20 °C

4.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

5.1: tetrahydrofuran; dichloromethane; water / 2 h / 20 °C / Cooling with ice

6.1: copper / N,N-dimethyl-formamide / 4 h / Inert atmosphere; Reflux

7.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

8.1: potassium carbonate / ethanol / 0.5 h / 20 °C

8.2: 10 h / Reflux

With sodium dihydrogenphosphate; thionyl chloride; palladium 10% on activated carbon; hydrogen; sodium acetate; iron; copper; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; 6.1: Ullmann condensation;
DOI:10.2174/157340611796150914

Reference yield:

: 1233979-41-3
6,6'-bis(benzyloxy)-5,5'-dimethoxy-N,N'-dimethylbiphenyl-2,2'-dicarboxamide

: 1326579-33-2
5,5'-dimethoxy-N,N'-dimethyl-6,6'-bis(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethoxy)biphenyl-2,2'-dicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2.1: potassium carbonate / ethanol / 0.5 h / 20 °C

2.2: 10 h / Reflux

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; ethanol;
DOI:10.2174/157340611796150914