Technology Process of (4R,6R)-4-(benzyloxymethyl)-2,2-dimethyl-6-(pentadec-2-ynyl)-1,3-dioxane
There total 10 articles about (4R,6R)-4-(benzyloxymethyl)-2,2-dimethyl-6-(pentadec-2-ynyl)-1,3-dioxane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
camphor-10-sulfonic acid;
In
dichloromethane;
at 20 ℃;
for 1.5h;
DOI:10.1039/c1ob05898c
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: pyridine; dmap / dichloromethane / 1.5 h / 20 °C
2.1: Er(OTf)2 / dichloromethane / 12 h / 20 °C
3.1: sodium periodate; silica gel / dichloromethane; water / 2.5 h / 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / -30 - 20 °C
5.1: dmap; di(n-butyl)tin oxide; triethylamine / acetonitrile / 1 h / 20 °C
6.1: potassium carbonate / methanol / 2.5 h / 20 °C / Cooling with ice
7.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
7.2: 5.5 h / -78 °C / Inert atmosphere
8.1: camphor-10-sulfonic acid / dichloromethane / 1.5 h / 20 °C
With
pyridine; dmap; sodium periodate; lithium aluminium tetrahydride; n-butyllithium; Er(OTf)2; camphor-10-sulfonic acid; silica gel; di(n-butyl)tin oxide; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;
DOI:10.1039/c1ob05898c
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hydride / tetrahydrofuran; dimethyl sulfoxide; mineral oil / 0.33 h / 20 °C
1.2: 24 h / 20 °C
2.1: pyridine; dmap / dichloromethane / 1.5 h / 20 °C
3.1: Er(OTf)2 / dichloromethane / 12 h / 20 °C
4.1: sodium periodate; silica gel / dichloromethane; water / 2.5 h / 20 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / -30 - 20 °C
6.1: dmap; di(n-butyl)tin oxide; triethylamine / acetonitrile / 1 h / 20 °C
7.1: potassium carbonate / methanol / 2.5 h / 20 °C / Cooling with ice
8.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
8.2: 5.5 h / -78 °C / Inert atmosphere
9.1: camphor-10-sulfonic acid / dichloromethane / 1.5 h / 20 °C
With
pyridine; dmap; sodium periodate; lithium aluminium tetrahydride; n-butyllithium; Er(OTf)2; camphor-10-sulfonic acid; silica gel; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; acetonitrile; mineral oil;
DOI:10.1039/c1ob05898c
