5-(3'-fluoro-4-((2-methoxyethoxy)methoxy)-[1,1'-biphenyl]-3-yl)-2-(trifluoromethyl)pyridine

Base Information

Chemical Name:5-(3'-fluoro-4-((2-methoxyethoxy)methoxy)-[1,1'-biphenyl]-3-yl)-2-(trifluoromethyl)pyridine
CAS No.:1609654-90-1
Molecular Formula:C₂₂H₁₉F₄NO₃
Molecular Weight:421.391
Hs Code.:

Synonyms:5-(3'-fluoro-4-((2-methoxyethoxy)methoxy)-[1,1'-biphenyl]-3-yl)-2-(trifluoromethyl)pyridine

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Chemical Property of 5-(3'-fluoro-4-((2-methoxyethoxy)methoxy)-[1,1'-biphenyl]-3-yl)-2-(trifluoromethyl)pyridine

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Technology Process of 5-(3'-fluoro-4-((2-methoxyethoxy)methoxy)-[1,1'-biphenyl]-3-yl)-2-(trifluoromethyl)pyridine

There total 3 articles about 5-(3'-fluoro-4-((2-methoxyethoxy)methoxy)-[1,1'-biphenyl]-3-yl)-2-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 868662-36-6
6-(trifluoromethyl)-3-pyridinylboronic acid

: 1609654-89-8
3-bromo-3'-fluoro-4-((2-methoxyethoxy)methoxy)-1,1'-biphenyl

: 1609654-90-1
5-(3'-fluoro-4-((2-methoxyethoxy)methoxy)-[1,1'-biphenyl]-3-yl)-2-(trifluoromethyl)pyridine

Guidance literature:: 6-(trifluoromethyl)-3-pyridinylboronic acid; 3-bromo-3'-fluoro-4-((2-methoxyethoxy)methoxy)-1,1'-biphenyl; With potassium carbonate; In 1,2-dimethoxyethane; water; for 0.333333h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 48h; Inert atmosphere; Sealed tube;

Reference yield:

: 64465-61-8
3'-fluoro-[1,1'-biphenyl]-4-ol

: 1609654-90-1
5-(3'-fluoro-4-((2-methoxyethoxy)methoxy)-[1,1'-biphenyl]-3-yl)-2-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine / dichloromethane; acetonitrile / 17 h / 0 - 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere

3.2: 48 h / 80 °C / Inert atmosphere; Sealed tube

With bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 3.1: |Suzuki Coupling / 3.2: |Suzuki Coupling;

Reference yield:

: 1609654-88-7
3-bromo-3'-fluoro-[1,1'-biphenyl]-4-ol

: 1609654-90-1
5-(3'-fluoro-4-((2-methoxyethoxy)methoxy)-[1,1'-biphenyl]-3-yl)-2-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere

2.2: 48 h / 80 °C / Inert atmosphere; Sealed tube

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; dichloromethane; water; 2.1: |Suzuki Coupling / 2.2: |Suzuki Coupling;