1-<2-(3-p-nitro-benzamidomethyl)-5,6-dihydro-4H-cyclopentathienyl>pyrrole

Base Information

• Chemical Name: 1-<2-(3-p-nitro-benzamidomethyl)-5,6-dihydro-4H-cyclopentathienyl>pyrrole
• CAS No.: 165820-30-4
• Molecular Formula: C₁₉H₁₇N₃O₃S
• Molecular Weight: 367.428

Synonyms:1-<2-(3-p-nitro-benzamidomethyl)-5,6-dihydro-4H-cyclopentathienyl>pyrrole

Chemical Property of 1-<2-(3-p-nitro-benzamidomethyl)-5,6-dihydro-4H-cyclopentathienyl>pyrrole

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Technology Process of 1-<2-(3-p-nitro-benzamidomethyl)-5,6-dihydro-4H-cyclopentathienyl>pyrrole

There total 3 articles about 1-<2-(3-p-nitro-benzamidomethyl)-5,6-dihydro-4H-cyclopentathienyl>pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-nitro-benzoyl chloride (122-04-3) + 1-<2-(3-aminomethyl)-5,6-dihydro-4H-cyclopenta-thienyl>pyrrole (165820-25-7) → 1-<2-(3-p-nitro-benzamidomethyl)-5,6-dihydro-4H-cyclopentathienyl>pyrrole (165820-30-4)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Ambient temperature;

Reference yield:

2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (70291-62-2) → 1-<2-(3-p-nitro-benzamidomethyl)-5,6-dihydro-4H-cyclopentathienyl>pyrrole (165820-30-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / glacial acetic acid / 0.5 h / Heating

2: 91 percent / LiAlH₄ / diethyl ether / 24 h / Heating

3: 78 percent / triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

With lithium aluminium tetrahydride; acetic acid; triethylamine; In diethyl ether; dichloromethane;

Reference yield:

1-<2-(5,6-dihydro-4H-cyclopentathienyl)-3-carbonitrile>pyrrole (165820-24-6) → 1-<2-(3-p-nitro-benzamidomethyl)-5,6-dihydro-4H-cyclopentathienyl>pyrrole (165820-30-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / LiAlH₄ / diethyl ether / 24 h / Heating

2: 78 percent / triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;

upstream raw materials:

4-nitro-benzoyl chloride

1-<2-(3-aminomethyl)-5,6-dihydro-4H-cyclopenta-thienyl>pyrrole

2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile

1-<2-(5,6-dihydro-4H-cyclopentathienyl)-3-carbonitrile>pyrrole

Downstream raw materials:

C₁₉H₁₇N₃O₂S

8,9-dihydro-4-p-nitrophenyl-6H,7H-pyrrolo<1,2-a>cyclopentathieno<3,2-f><1,4>diazepine

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