benzyl 5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

Base Information

Chemical Name:benzyl 5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate
CAS No.:1361236-58-9
Molecular Formula:C₂₂H₂₁N₃O₅
Molecular Weight:407.426
Hs Code.:

Synonyms:benzyl 5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

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Chemical Property of benzyl 5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

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Technology Process of benzyl 5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

There total 2 articles about benzyl 5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 74124-79-1
di(succinimido) carbonate

: 1361236-55-6
benzyl 1-(3-amino-2-hydroxypropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

: 1361236-58-9
benzyl 5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 23 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/jm201331s

Reference yield:

: 1034355-97-9
benzyl 1-(3-chloro-2-hydroxypropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

: 1361236-58-9
benzyl 5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / water; N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

2: 1.3-propanedithiol; N-ethyl-N,N-diisopropylamine / methanol / 48 h / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 1.5 h / 23 °C / Inert atmosphere

With 1.3-propanedithiol; sodium azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm201331s

Reference yield: 100.0%

: 1361236-58-9
benzyl 5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

: 1361236-59-0
5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Guidance literature:: benzyl 5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate; In methanol; for 0.333333h;

With palladium 10% on activated carbon; hydrogen; In methanol; at 23 ℃; for 18h;
DOI:10.1021/jm201331s