(4R)-4-methyl-4-(2-{1-methyl-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl}ethyl)-1,3-oxazolidin-2-one

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Chemical Name:(4R)-4-methyl-4-(2-{1-methyl-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl}ethyl)-1,3-oxazolidin-2-one
CAS No.:1378964-52-3
Molecular Formula:C₂₂H₂₈N₂O₃
Molecular Weight:368.476
Hs Code.:

Synonyms:(4R)-4-methyl-4-(2-{1-methyl-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl}ethyl)-1,3-oxazolidin-2-one

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Chemical Property of (4R)-4-methyl-4-(2-{1-methyl-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl}ethyl)-1,3-oxazolidin-2-one

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Technology Process of (4R)-4-methyl-4-(2-{1-methyl-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl}ethyl)-1,3-oxazolidin-2-one

There total 4 articles about (4R)-4-methyl-4-(2-{1-methyl-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl}ethyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

: methyl (2R,4R)-2-t-butyl-4-methyl-4-(2-{1-methyl-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl}ethyl)-1,3-oxazolidine-3-carboxylate

: 1378964-52-3
(4R)-4-methyl-4-(2-{1-methyl-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl}ethyl)-1,3-oxazolidin-2-one

Guidance literature:: methyl (2R,4R)-2-t-butyl-4-methyl-4-(2-{1-methyl-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl}ethyl)-1,3-oxazolidine-3-carboxylate; With hydrogenchloride; water; In methanol; at 45 - 50 ℃; for 2.5h;

With water; sodium hydroxide; In methanol; at 45 - 50 ℃; for 2h;

Reference yield: 88.6%

: methyl (2R,4R)-2-tert-butyl-4-methyl-4-[2-(1-methyl-1H-pyrrol-2-yl)ethyl]-1,3-oxazolidine-3-carboxylate

: 160699-02-5
4-(4-methylphenyl)butanoyl chloride

: 1378964-52-3
(4R)-4-methyl-4-(2-{1-methyl-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl}ethyl)-1,3-oxazolidin-2-one

Guidance literature:: methyl (2R,4R)-2-tert-butyl-4-methyl-4-[2-(1-methyl-1H-pyrrol-2-yl)ethyl]-1,3-oxazolidine-3-carboxylate; 4-(4-methylphenyl)butanoyl chloride; for 8h; under 337.534 - 412.541 Torr; Inert atmosphere; Reflux;

With hydrogenchloride; water; In methanol; at 50 ℃; for 2.5h; Inert atmosphere;

With water; sodium hydroxide; In methanol; at 50 ℃; for 1h; Inert atmosphere;

Reference yield:

: 4521-22-6
4-(4-methylphenyl)butyric acid

: 1378964-52-3
(4R)-4-methyl-4-(2-{1-methyl-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl}ethyl)-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / methyl cyclohexane; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2.1: 8 h / 337.53 - 412.54 Torr / Inert atmosphere; Reflux

2.2: 2.5 h / 50 °C / Inert atmosphere

2.3: 1 h / 50 °C / Inert atmosphere

With oxalyl dichloride; In methyl cyclohexane; N,N-dimethyl-formamide;