Technology Process of 3-[(2R,4R)-2-(hydroxymethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidin-1-yl]propanenitrile
There total 6 articles about 3-[(2R,4R)-2-(hydroxymethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidin-1-yl]propanenitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
water;
1.) ice-bath, 1 h, 2.) without ice-bath 1 h;
DOI:10.1021/jm00128a015
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 97.3 percent / H2 / 10percent Pd/C / methanol / 16 h / 760 Torr / Ambient temperature
2: 90 percent / benzene; dimethylformamide; diethyl ether / 1.) -15 deg C, 2 h, 2.) 5 deg C, overnight
3: 89 percent / 15 N aq. NH4OH / 16 h / Heating
4: phenol, HBr, acetic acid / 16 h / 90 °C
5: 73.9 percent / H2O / 1.) ice-bath, 1 h, 2.) without ice-bath 1 h
With
ammonium hydroxide; hydrogen bromide; hydrogen; acetic acid; phenol;
palladium on activated charcoal;
In
methanol; diethyl ether; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00128a015
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / benzene; dimethylformamide; diethyl ether / 1.) -15 deg C, 2 h, 2.) 5 deg C, overnight
2: 89 percent / 15 N aq. NH4OH / 16 h / Heating
3: phenol, HBr, acetic acid / 16 h / 90 °C
4: 73.9 percent / H2O / 1.) ice-bath, 1 h, 2.) without ice-bath 1 h
With
ammonium hydroxide; hydrogen bromide; acetic acid; phenol;
In
diethyl ether; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00128a015
