(R,R)-N-boc-N'-(3-chloroacetylaminophenylsulfonyl)-1,2-diaminocyclohexane

Base Information

• Chemical Name: (R,R)-N-boc-N'-(3-chloroacetylaminophenylsulfonyl)-1,2-diaminocyclohexane
• CAS No.: 1260172-68-6
• Molecular Formula: C₁₉H₂₈ClN₃O₅S
• Molecular Weight: 445.967

Synonyms:(R,R)-N-boc-N'-(3-chloroacetylaminophenylsulfonyl)-1,2-diaminocyclohexane

Chemical Property of (R,R)-N-boc-N'-(3-chloroacetylaminophenylsulfonyl)-1,2-diaminocyclohexane

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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Technology Process of (R,R)-N-boc-N'-(3-chloroacetylaminophenylsulfonyl)-1,2-diaminocyclohexane

There total 5 articles about (R,R)-N-boc-N'-(3-chloroacetylaminophenylsulfonyl)-1,2-diaminocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

(R,R)-N-boc-N'-(3-aminophenylsulfonyl)-1,2-diaminocyclohexane (1260172-67-5) + chloroacetyl chloride (79-04-9) → (R,R)-N-boc-N'-(3-chloroacetylaminophenylsulfonyl)-1,2-diaminocyclohexane (1260172-68-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 40h; Cooling with ice;

DOI:10.1002/hc.20641

Reference yield:

(R,R)-N-(3-nitrophenylsulfonyl)-1,2-diaminocyclohexane (1260172-65-3) → (R,R)-N-boc-N'-(3-chloroacetylaminophenylsulfonyl)-1,2-diaminocyclohexane (1260172-68-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C

2: 10% palladium on activated charcoal; ammonium formate / methanol / 20 °C

3: triethylamine / dichloromethane / 40 h / 20 °C / Cooling with ice

With 10% palladium on activated charcoal; ammonium formate; triethylamine; In methanol; dichloromethane;

DOI:10.1002/hc.20641

Reference yield:

(R,R)-N-boc-N'-(3-nitrophenylsulfonyl)-1,2-diaminocyclohexane (1260172-66-4) → (R,R)-N-boc-N'-(3-chloroacetylaminophenylsulfonyl)-1,2-diaminocyclohexane (1260172-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 10% palladium on activated charcoal; ammonium formate / methanol / 20 °C

2: triethylamine / dichloromethane / 40 h / 20 °C / Cooling with ice

With 10% palladium on activated charcoal; ammonium formate; triethylamine; In methanol; dichloromethane;

DOI:10.1002/hc.20641

upstream raw materials:

(R,R)-N-(3-nitrophenylsulfonyl)-1,2-diaminocyclohexane

(R,R)-N-boc-N'-(3-nitrophenylsulfonyl)-1,2-diaminocyclohexane

(R,R)-N-boc-N'-(3-aminophenylsulfonyl)-1,2-diaminocyclohexane

chloroacetyl chloride

Downstream raw materials:

C₂₃H₃₄N₅O₅S⁽¹⁺⁾*Cl^(1-)

C₂F₃O₂^(1-)*C₂HF₃O₂*C₁₈H₂₆N₅O₃S⁽¹⁺⁾

C₂F₃O₂^(1-)*C₂HF₃O₂*C₁₉H₂₅N₄O₃S⁽¹⁺⁾

C₂F₃O₂^(1-)*C₂HF₃O₂*C₂₀H₃₅N₄O₃S⁽¹⁺⁾

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