(R)-ethyl 1-benzyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

Base Information

Chemical Name:(R)-ethyl 1-benzyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
CAS No.:1248337-48-5
Molecular Formula:C₂₂H₂₂N₂O₄
Molecular Weight:378.428
Hs Code.:

Synonyms:(R)-ethyl 1-benzyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

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Chemical Property of (R)-ethyl 1-benzyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

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Technology Process of (R)-ethyl 1-benzyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

There total 4 articles about (R)-ethyl 1-benzyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1734-79-8
3-(4-nitrophenyl)-2-propenal

: 21759-74-0
ethyl (Z)-3-(benzylamino)-2-butenoate

: 1248337-48-5
(R)-ethyl 1-benzyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

: 1268723-76-7
(S)-ethyl 1-benzyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

Guidance literature:: With Difluoroacetic acid; C₂₇H₃₃F₆N₃O₂S; In toluene; at 20 ℃; for 12.5h; optical yield given as %ee; enantioselective reaction;
DOI:10.1055/s-0030-1258090

Reference yield:

: 1734-79-8
3-(4-nitrophenyl)-2-propenal

: 1020-67-3
ethyl 3-(benzylamino)crotonate

: 1248337-48-5
(R)-ethyl 1-benzyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

: 1268723-76-7
(S)-ethyl 1-benzyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

Guidance literature:: With (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether; benzoic acid; In toluene; at 20 ℃; for 3h; Overall yield = 70 %; Overall yield = 132 mg; enantioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201402607

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1248337-48-5
(R)-ethyl 1-benzyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

: 1268723-76-7
(S)-ethyl 1-benzyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water

2.1: (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; benzoic acid / toluene / 0.08 h / Inert atmosphere

2.2: 4 h / 20 °C / Inert atmosphere

With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; benzoic acid; In water; toluene;
DOI:10.1021/jo200095e