2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(piperidin-2''''-on-1''''-yl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

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Chemical Name:2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(piperidin-2''''-on-1''''-yl)phenyl]-1,4:3,6-dianhydro-D-sorbitole
CAS No.:745794-66-5
Molecular Formula:C₂₆H₂₇N₃O₆
Molecular Weight:477.517
Hs Code.:

Synonyms:2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(piperidin-2''''-on-1''''-yl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

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Chemical Property of 2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(piperidin-2''''-on-1''''-yl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

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Technology Process of 2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(piperidin-2''''-on-1''''-yl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

There total 8 articles about 2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(piperidin-2''''-on-1''''-yl)phenyl]-1,4:3,6-dianhydro-D-sorbitole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 745794-66-5
2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(piperidin-2''''-on-1''''-yl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 1 h / 60 °C

1.2: 92 percent / dimethylformamide / 60 °C

2.1: H₂ / Pd/C / methanol; tetrahydrofuran / 0.5 h / 750.06 Torr

3.1: 4.46 g / KNO₂; KI; aq. HBr / dimethylsulfoxide / 0.5 h / 50 °C

4.1: 65 percent / CuI; trans-1,2-cyclohexanediamine; K₃PO₄ / dioxane / 24 h / Heating

5.1: H₂ / Pd(OH)2/C / methanol; ethyl acetate / 750.06 Torr

6.1: 337 mg / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 40 °C

With potassium phosphate; copper(l) iodide; potassium nitrite; di-isopropyl azodicarboxylate; (S,S)-1,2-diaminocyclohexane; hydrogen bromide; hydrogen; sodium hydride; triphenylphosphine; potassium iodide; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 6.1: Mitsunobu reaction;

Reference yield:

: 183624-93-3
(3R,3aR,6R,6aR)-6-benzyloxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol

: 745794-66-5
2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(piperidin-2''''-on-1''''-yl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 1 h / 60 °C

1.2: 92 percent / dimethylformamide / 60 °C

2.1: H₂ / Pd/C / methanol; tetrahydrofuran / 0.5 h / 750.06 Torr

3.1: 4.46 g / KNO₂; KI; aq. HBr / dimethylsulfoxide / 0.5 h / 50 °C

4.1: 65 percent / CuI; trans-1,2-cyclohexanediamine; K₃PO₄ / dioxane / 24 h / Heating

5.1: H₂ / Pd(OH)2/C / methanol; ethyl acetate / 750.06 Torr

6.1: 337 mg / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 40 °C

With potassium phosphate; copper(l) iodide; potassium nitrite; di-isopropyl azodicarboxylate; (S,S)-1,2-diaminocyclohexane; hydrogen bromide; hydrogen; sodium hydride; triphenylphosphine; potassium iodide; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 6.1: Mitsunobu reaction;

Reference yield:

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 745794-66-5
2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(piperidin-2''''-on-1''''-yl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / dimethylformamide / 80 °C

1.2: 48 percent / TBAI / dimethylformamide / 18 h / 20 °C

2.1: NaH / dimethylformamide / 1 h / 60 °C

2.2: 92 percent / dimethylformamide / 60 °C

3.1: H₂ / Pd/C / methanol; tetrahydrofuran / 0.5 h / 750.06 Torr

4.1: 4.46 g / KNO₂; KI; aq. HBr / dimethylsulfoxide / 0.5 h / 50 °C

5.1: 65 percent / CuI; trans-1,2-cyclohexanediamine; K₃PO₄ / dioxane / 24 h / Heating

6.1: H₂ / Pd(OH)2/C / methanol; ethyl acetate / 750.06 Torr

7.1: 337 mg / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 40 °C

With potassium phosphate; copper(l) iodide; potassium nitrite; di-isopropyl azodicarboxylate; (S,S)-1,2-diaminocyclohexane; hydrogen bromide; hydrogen; sodium hydride; triphenylphosphine; potassium iodide; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 7.1: Mitsunobu reaction;