N-(3-tosyloxyphenethyl)-2-(2-bromo-3-isopropoxy-4-methoxyphenyl)acetamide

Base Information

Chemical Name:N-(3-tosyloxyphenethyl)-2-(2-bromo-3-isopropoxy-4-methoxyphenyl)acetamide
CAS No.:93710-59-9
Molecular Formula:C₂₇H₃₀BrNO₆S
Molecular Weight:576.508
Hs Code.:

Synonyms:N-(3-tosyloxyphenethyl)-2-(2-bromo-3-isopropoxy-4-methoxyphenyl)acetamide

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Chemical Property of N-(3-tosyloxyphenethyl)-2-(2-bromo-3-isopropoxy-4-methoxyphenyl)acetamide

Chemical Property:

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Technology Process of N-(3-tosyloxyphenethyl)-2-(2-bromo-3-isopropoxy-4-methoxyphenyl)acetamide

There total 12 articles about N-(3-tosyloxyphenethyl)-2-(2-bromo-3-isopropoxy-4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 93710-49-7
3-tosyloxyphenethylamine

: 93710-58-8
2-bromo-3-isopropoxy-4-methoxyphenylacetic acid

: 93710-59-9
N-(3-tosyloxyphenethyl)-2-(2-bromo-3-isopropoxy-4-methoxyphenyl)acetamide

Guidance literature:: In decalin; for 2.5h; Heating;
DOI:10.1016/S0031-9422(00)82630-8

Reference yield:

: 2973-58-2
2-bromoisovanillin

: 93710-59-9
N-(3-tosyloxyphenethyl)-2-(2-bromo-3-isopropoxy-4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / K₂CO₃ / dimethylformamide / r.t., 45 min, 100 deg C, 2 h

2: 100 percent / NaBH₄ / ethanol / 1 h

3: 96 percent / pyridine, SOCl₂ / diethyl ether / 0.33 h / Ambient temperature

4: 95 percent / dimethylsulfoxide / 18 h / Ambient temperature

5: 90 percent / ethylene glycol, H₂O, KOH / 2 h / Heating

6: 84 percent / decahydronaphthalene / 2.5 h / Heating

With pyridine; potassium hydroxide; sodium tetrahydroborate; thionyl chloride; water; potassium carbonate; ethylene glycol; In diethyl ether; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; decalin;
DOI:10.1016/S0031-9422(00)82630-8

Reference yield:

: 80459-46-7
3-formylphenyl 4-methylbenzenesulfonate

: 93710-59-9
N-(3-tosyloxyphenethyl)-2-(2-bromo-3-isopropoxy-4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / 1.25 h / 0 °C

2: 95 percent / pyridine, SOCl₂ / diethyl ether / 0.33 h / Ambient temperature

3: 86 percent / dimethylsulfoxide / 18 h / Ambient temperature

4: 100 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / 144 h / Ambient temperature

5: 84 percent / decahydronaphthalene / 2.5 h / Heating

With pyridine; sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; decalin;
DOI:10.1016/S0031-9422(00)82630-8