(2R,3R)-1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

Base Information

Chemical Name:(2R,3R)-1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione
CAS No.:1374418-71-9
Molecular Formula:C₁₈H₁₅NO₃
Molecular Weight:293.322
Hs Code.:

Synonyms:(2R,3R)-1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

Chemical Property:

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Technology Process of (2R,3R)-1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

There total 21 articles about (2R,3R)-1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 3335-86-2,114581-75-8,124508-46-9
3-hydroxy-1-methyl-indolin-2-one

: 103-26-4,1754-62-7
Methyl cinnamate

: 1374418-71-9
(2R,3R)-1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

: methyl 3-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)-3-phenylpropanoate

: 1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

Guidance literature:: With (R,R)-(-)-2,6-bis[2-(hydroxyldiphenylmethyl)-1-pyrrolidinyl-methyl]-4-methylphenole; diethylzinc; In hexane; toluene; acetonitrile; at 20 ℃; for 36h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol300577y

Reference yield:

: 2757-04-2,25695-77-6
phenyl cinnamate

: 3335-86-2,114581-75-8,124508-46-9
3-hydroxy-1-methyl-indolin-2-one

: 1374418-71-9
(2R,3R)-1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

Guidance literature:: With (R,R)-(-)-2,6-bis[2-(hydroxyldiphenylmethyl)-1-pyrrolidinyl-methyl]-4-methylphenole; diethylzinc; In hexane; dichloromethane; toluene; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol300577y

Reference yield:

: 2757-04-2,25695-77-6
phenyl cinnamate

: 3335-86-2,114581-75-8,124508-46-9
3-hydroxy-1-methyl-indolin-2-one

: 1360768-91-7
(2S,3S)-1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

: 1374418-71-9
(2R,3R)-1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

: 1'-methyl-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

Guidance literature:: With (R,R)-(-)-2,6-bis[2-(hydroxyldiphenylmethyl)-1-pyrrolidinyl-methyl]-4-methylphenole; dibutylmagnesium; In hexane; toluene; acetonitrile; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol300577y