(3R,4S)-4-(4-Fluoro-phenylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

Base Information

Chemical Name:(3R,4S)-4-(4-Fluoro-phenylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile
CAS No.:180681-93-0
Molecular Formula:C₁₈H₁₇FN₂O₂
Molecular Weight:312.344
Hs Code.:

Synonyms:(3R,4S)-4-(4-Fluoro-phenylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

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Chemical Property of (3R,4S)-4-(4-Fluoro-phenylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

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Technology Process of (3R,4S)-4-(4-Fluoro-phenylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

There total 1 articles about (3R,4S)-4-(4-Fluoro-phenylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 65018-90-8,75611-72-2,114926-02-2,114926-03-3
(1aR-cis)-1a,7b-dihydro-2,2-dimethyl-2H-oxireno[c][1]benzopyran-6-carbonitrile

: 371-40-4
4-fluoroaniline

: 180681-93-0
(3R,4S)-4-(4-Fluoro-phenylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

Guidance literature:: With magnesium(II) perchlorate; In acetonitrile; for 48h; Ambient temperature;
DOI:10.1021/jm9605905

Reference yield:

: 180681-93-0
(3R,4S)-4-(4-Fluoro-phenylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

: 185690-30-6
N-[(3R,4S)-6-Cyano-3-(4-methoxy-benzyloxy)-2,2-dimethyl-chroman-4-yl]-N-(4-fluoro-phenyl)-oxalamic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 10 min, 2.) DMF, RT, 1 h

2: DMAP / acetonitrile / 4 h / Ambient temperature

With dmap; sodium hydride; In acetonitrile;
DOI:10.1021/jm9605905

Reference yield:

: 180681-93-0
(3R,4S)-4-(4-Fluoro-phenylamino)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

: N-((3R,4S)-6-Cyano-3-hydroxy-2,2-dimethyl-chroman-4-yl)-N-(4-fluoro-phenyl)-oxalamic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 10 min, 2.) DMF, RT, 1 h

2: DMAP / acetonitrile / 4 h / Ambient temperature

3: 55 percent / TFA / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; sodium hydride; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jm9605905