2-(4-fluorophenyl)-6-[(4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl]-5-phenyl-1-benzofuran-3-carboxylic acid

Base Information

Chemical Name:2-(4-fluorophenyl)-6-[(4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl]-5-phenyl-1-benzofuran-3-carboxylic acid
CAS No.:1333225-04-9
Molecular Formula:C₃₁H₂₂FNO₅
Molecular Weight:507.518
Hs Code.:

Synonyms:2-(4-fluorophenyl)-6-[(4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl]-5-phenyl-1-benzofuran-3-carboxylic acid

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Chemical Property of 2-(4-fluorophenyl)-6-[(4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl]-5-phenyl-1-benzofuran-3-carboxylic acid

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Technology Process of 2-(4-fluorophenyl)-6-[(4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl]-5-phenyl-1-benzofuran-3-carboxylic acid

There total 6 articles about 2-(4-fluorophenyl)-6-[(4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl]-5-phenyl-1-benzofuran-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333225-03-8
ethyl 2-(4-fluorophenyl)-6-((4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl)-5-phenyl-1-benzofuran-3-carboxylate

: 1333225-04-9
2-(4-fluorophenyl)-6-[(4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl]-5-phenyl-1-benzofuran-3-carboxylic acid

Guidance literature:: ethyl 2-(4-fluorophenyl)-6-((4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl)-5-phenyl-1-benzofuran-3-carboxylate; With water; lithium hydroxide; In 1,4-dioxane; at 100 ℃; for 3h;

With hydrogenchloride; In water; pH=3;

Reference yield:

: 98-80-6
phenylboronic acid

: 1333225-04-9
2-(4-fluorophenyl)-6-[(4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl]-5-phenyl-1-benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2.1: water; iron; ammonium chloride / tetrahydrofuran; methanol / 4 h / Reflux

3.1: sulfuric acid; sodium nitrite / water / 0.52 h / 0 °C

3.2: 3.08 h / 0 - 20 °C

4.1: copper(l) iodide; potassium carbonate / nitrobenzene / 6 h / 180 °C

5.1: water; lithium hydroxide / 1,4-dioxane / 3 h / 100 °C

5.2: pH 3

With copper(l) iodide; potassium phosphate tribasic trihydrate; sulfuric acid; water; iron; potassium carbonate; ammonium chloride; lithium hydroxide; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; water; nitrobenzene; N,N-dimethyl-formamide;

Reference yield:

: 691857-51-9
ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

: 1333225-04-9
2-(4-fluorophenyl)-6-[(4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl]-5-phenyl-1-benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2.1: water; iron; ammonium chloride / tetrahydrofuran; methanol / 4 h / Reflux

3.1: sulfuric acid; sodium nitrite / water / 0.52 h / 0 °C

3.2: 3.08 h / 0 - 20 °C

4.1: copper(l) iodide; potassium carbonate / nitrobenzene / 6 h / 180 °C

5.1: water; lithium hydroxide / 1,4-dioxane / 3 h / 100 °C

5.2: pH 3

With copper(l) iodide; potassium phosphate tribasic trihydrate; sulfuric acid; water; iron; potassium carbonate; ammonium chloride; lithium hydroxide; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; water; nitrobenzene; N,N-dimethyl-formamide;