ethyl 2-(4-fluorophenyl)-6-((4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl)-5-phenyl-1-benzofuran-3-carboxylate

Base Information

Chemical Name:ethyl 2-(4-fluorophenyl)-6-((4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl)-5-phenyl-1-benzofuran-3-carboxylate
CAS No.:1333225-03-8
Molecular Formula:C₃₃H₂₆FNO₅
Molecular Weight:535.572
Hs Code.:

Synonyms:ethyl 2-(4-fluorophenyl)-6-((4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl)-5-phenyl-1-benzofuran-3-carboxylate

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Chemical Property of ethyl 2-(4-fluorophenyl)-6-((4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl)-5-phenyl-1-benzofuran-3-carboxylate

Chemical Property:

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Technology Process of ethyl 2-(4-fluorophenyl)-6-((4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl)-5-phenyl-1-benzofuran-3-carboxylate

There total 5 articles about ethyl 2-(4-fluorophenyl)-6-((4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl)-5-phenyl-1-benzofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 16251-45-9,17097-67-5,28044-22-6,28044-23-7,39663-75-7,54418-69-8,77943-39-6,125133-96-2,149055-02-7
(4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one

: 1333225-02-7
ethyl 2-(4-fluorophenyl)-6-iodo-5-phenyl-1-benzofuran-3-carboxylate

: 1333225-03-8
ethyl 2-(4-fluorophenyl)-6-((4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl)-5-phenyl-1-benzofuran-3-carboxylate

Guidance literature:: With copper(l) iodide; potassium carbonate; In nitrobenzene; at 180 ℃; for 6h;

Reference yield:

: 98-80-6
phenylboronic acid

: 1333225-03-8
ethyl 2-(4-fluorophenyl)-6-((4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl)-5-phenyl-1-benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2.1: water; iron; ammonium chloride / tetrahydrofuran; methanol / 4 h / Reflux

3.1: sulfuric acid; sodium nitrite / water / 0.52 h / 0 °C

3.2: 3.08 h / 0 - 20 °C

4.1: copper(l) iodide; potassium carbonate / nitrobenzene / 6 h / 180 °C

With copper(l) iodide; potassium phosphate tribasic trihydrate; sulfuric acid; water; iron; potassium carbonate; ammonium chloride; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; water; nitrobenzene; N,N-dimethyl-formamide;

Reference yield:

: 691857-51-9
ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

: 1333225-03-8
ethyl 2-(4-fluorophenyl)-6-((4S,5R)-4-methyl-2-oxo-5-phenyl-1,3-oxazolidin-3-yl)-5-phenyl-1-benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2.1: water; iron; ammonium chloride / tetrahydrofuran; methanol / 4 h / Reflux

3.1: sulfuric acid; sodium nitrite / water / 0.52 h / 0 °C

3.2: 3.08 h / 0 - 20 °C

4.1: copper(l) iodide; potassium carbonate / nitrobenzene / 6 h / 180 °C

With copper(l) iodide; potassium phosphate tribasic trihydrate; sulfuric acid; water; iron; potassium carbonate; ammonium chloride; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; water; nitrobenzene; N,N-dimethyl-formamide;