2-(5-(2-hydroxyethoxy)-6-(3-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one methanesulfonate

Base Information

Chemical Name:2-(5-(2-hydroxyethoxy)-6-(3-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one methanesulfonate
CAS No.:1610372-62-7
Molecular Formula:CH₄O₃S*C₂₄H₂₃N₃O₇S
Molecular Weight:593.635
Hs Code.:

Synonyms:2-(5-(2-hydroxyethoxy)-6-(3-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one methanesulfonate

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Chemical Property of 2-(5-(2-hydroxyethoxy)-6-(3-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one methanesulfonate

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Technology Process of 2-(5-(2-hydroxyethoxy)-6-(3-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one methanesulfonate

There total 8 articles about 2-(5-(2-hydroxyethoxy)-6-(3-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1610372-61-6
2-(5-(2-hydroxyethoxy)-6-(3-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one

: 1610372-62-7
2-(5-(2-hydroxyethoxy)-6-(3-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one methanesulfonate

Guidance literature:: In methanol; dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 168015-04-1
2-bromo-6-(hydroxymethyl)pyridin-3-ol

: 1610372-62-7
2-(5-(2-hydroxyethoxy)-6-(3-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 20 h / 60 °C / Inert atmosphere

2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; toluene / 16 h / 90 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 18 h / 120 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6.1: dichloromethane; methanol / 2 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1610372-62-7
2-(5-(2-hydroxyethoxy)-6-(3-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide; ethylenediaminetetraacetic acid disodium salt dihydrate / water / 5 h / 90 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 20 h / 60 °C / Inert atmosphere

3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; toluene / 16 h / 90 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 18 h / 120 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

7.1: dichloromethane; methanol / 2 h / 20 °C / Inert atmosphere

With ethylenediaminetetraacetic acid disodium salt dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;