(S)-ethyl 5-(benzyloxy)-2-(4-(benzyloxy)benzoyl)-5-(4-fluorophenyl)pentanoate

Base Information

• Chemical Name: (S)-ethyl 5-(benzyloxy)-2-(4-(benzyloxy)benzoyl)-5-(4-fluorophenyl)pentanoate
• CAS No.: 1238698-16-2
• Molecular Formula: C₃₄H₃₃FO₅
• Molecular Weight: 540.631
• Mol file: 1238698-16-2.mol

Synonyms:(S)-ethyl 5-(benzyloxy)-2-(4-(benzyloxy)benzoyl)-5-(4-fluorophenyl)pentanoate

Chemical Property of (S)-ethyl 5-(benzyloxy)-2-(4-(benzyloxy)benzoyl)-5-(4-fluorophenyl)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (S)-ethyl 5-(benzyloxy)-2-(4-(benzyloxy)benzoyl)-5-(4-fluorophenyl)pentanoate

There total 1 articles about (S)-ethyl 5-(benzyloxy)-2-(4-(benzyloxy)benzoyl)-5-(4-fluorophenyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-(((S)-1-(4-fluorophenyl)-3-iodopropoxy)methyl)benzene (1238698-11-7) + ethyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate (53090-45-2) → (S)-ethyl 5-(benzyloxy)-2-(4-(benzyloxy)benzoyl)-5-(4-fluorophenyl)pentanoate (1238698-16-2)

Guidance literature:

ethyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate; With potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; at 20 ℃; Inert atmosphere;

1-(((S)-1-(4-fluorophenyl)-3-iodopropoxy)methyl)benzene; at 20 ℃; Inert atmosphere;

Reference yield: 91.0%

(S)-ethyl 5-(benzyloxy)-2-(4-(benzyloxy)benzoyl)-5-(4-fluorophenyl)pentanoate (1238698-16-2) + 4-fluoroaniline (371-40-4) → (S,Z)-ethyl 5-(benzyloxy)-2-((4-(benzyloxy)phenyl)(4-fluorophenylamino)methylene)-5-(4-fluorophenyl)pentanoate (1238698-23-1)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In toluene; for 16h; Reflux;

upstream raw materials:

1-(((S)-1-(4-fluorophenyl)-3-iodopropoxy)methyl)benzene

ethyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate

Downstream raw materials:

(S,Z)-ethyl 5-(benzyloxy)-2-((4-(benzyloxy)phenyl)(4-fluorophenylamino)methylene)-5-(4-fluorophenyl)pentanoate