(2R,3R,4S)-4-Benzyloxy-2-chloro-3-hydroxy-pentanoic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester

Base Information

Chemical Name:(2R,3R,4S)-4-Benzyloxy-2-chloro-3-hydroxy-pentanoic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester
CAS No.:745831-98-5
Molecular Formula:C₂₈H₃₀ClNO₆S
Molecular Weight:544.068
Hs Code.:

Synonyms:(2R,3R,4S)-4-Benzyloxy-2-chloro-3-hydroxy-pentanoic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester

Suppliers and Price of (2R,3R,4S)-4-Benzyloxy-2-chloro-3-hydroxy-pentanoic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R,4S)-4-Benzyloxy-2-chloro-3-hydroxy-pentanoic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,4S)-4-Benzyloxy-2-chloro-3-hydroxy-pentanoic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester

There total 3 articles about (2R,3R,4S)-4-Benzyloxy-2-chloro-3-hydroxy-pentanoic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 81445-44-5
(S)-2-(benzyloxy)propanal

: 745831-83-8
Chloro-acetic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester

: 745831-98-5
(2R,3R,4S)-4-Benzyloxy-2-chloro-3-hydroxy-pentanoic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester

Guidance literature:: Chloro-acetic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester; With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

(S)-2-(benzyloxy)propanal; With titanium tetrachloride; In dichloromethane; at -78 ℃; for 0.0833333h;
DOI:10.1021/ol0490835

Reference yield: 40.0%

: 53346-05-7
2-(benzyloxy)propanal

: 745831-83-8
Chloro-acetic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester

: 81445-44-5
(S)-2-(benzyloxy)propanal

: 745831-98-5
(2R,3R,4S)-4-Benzyloxy-2-chloro-3-hydroxy-pentanoic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester

: 745832-02-4
(2R,3S,4R)-4-Benzyloxy-2-chloro-3-hydroxy-pentanoic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester

Guidance literature:: Chloro-acetic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester; With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

2-(benzyloxy)propanal; With titanium tetrachloride; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1021/ol0490835

Reference yield:

: 175523-35-0
(+)-(1R,2S)-1-(N-tosylamino)-2-indanol

: 745831-98-5
(2R,3R,4S)-4-Benzyloxy-2-chloro-3-hydroxy-pentanoic acid (1R,2S)-1-(toluene-4-sulfonylamino)-indan-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

2.1: TiCl₄; iPr₂NEt / CH₂Cl₂ / 0 °C

2.2: 82 percent / TiCl₄ / CH₂Cl₂ / 0.08 h / -78 °C

With pyridine; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ol0490835