16927-13-2

Basic information

• Product Name: 2-BROMO-2-PHENYLACETALDEHYDE
• Synonyms: 2-BROMO-2-PHENYLACETALDEHYDE;Benzeneacetaldehyde, a-broMo-
• CAS NO: 16927-13-2
• Molecular Formula: C₈H₇BrO
• Molecular Weight: 199.04458
• Mol File: 16927-13-2.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BROMO-2-PHENYLACETALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-2-PHENYLACETALDEHYDE(16927-13-2)
• EPA Substance Registry System: 2-BROMO-2-PHENYLACETALDEHYDE(16927-13-2)

Safety Data

• Hazardous Substances Data: 16927-13-2(Hazardous Substances Data)

Usage

General Description

2-Bromo-2-phenylacetaldehyde is a chemical compound with the molecular formula C8H7BrO. It is a colorless liquid with a strong, sweet odor, and is insoluble in water. 2-BROMO-2-PHENYLACETALDEHYDE is used in organic synthesis as a reagent for the preparation of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the production of fragrances and flavors. 2-Bromo-2-phenylacetaldehyde is classified as a hazardous chemical and should be handled with caution due to its potential for skin and eye irritation, as well as its flammability.

Upstream product

• 122-78-1 phenylacetaldehyde 
• 67-66-3 chloroform 
• 124-38-9 carbon dioxide 
• 7726-95-6 bromine 
• 96-09-3 styrene oxide 
• 101-48-4 phenylacetaldehyde dimethyl acetal 
• 14371-25-6 2-bromo-1,1-dimethoxy-2-phenylethane 
• 18756-03-1 (E)-(2-azidovinyl)benzene 
• 82737-11-9 (+/-)-2-phenylselenophenyacetaldehyde 
• 4747-15-3 1-(2-methoxyvinyl)benzene 
• 61937-46-0 2-phenyl-1-(phenylsulfonyl)-1,2-epoxyethane 
• 14371-19-8 cis-β-methoxystyrene 

Downstream Products

• 1826-13-7 5-phenylthiazole 
• 31327-12-5 E-Dimethyl-styryl-phosphat 
• 69814-24-0 4-Formyl-4-phenylbutan-2-one 
• 63735-73-9 5-phenyl-imidazo[2,1-b][1,3,4]thiadiazole-2-sulfonic acid amide 
• 62910-84-3 2-Carboxymethylmercapto-2-phenyl-acetaldehyd 
• 62910-85-4 2-benzylsulfanyl-2-phenylacetaldehyde 
• 322408-28-6 7-(1-bromo-1-phenylmethyl)-5,9-dihydro-6,8-dioxa-benzocycloheptene 
• 322408-31-1 7-benzylidene-5,9-dihydro-6,8-dioxa-benzocycloheptene 
• 322408-49-1 C₁₈H₁₅NO₂ 
• 322408-50-4 C₁₈H₁₇NO₃ 
• 322408-51-5 C₁₉H₁₉NO₄ 
• 122-78-1 phenylacetaldehyde 
• 3704-40-3 2,5-diphenyl-1,3-thiazole 

Relevant articles and documents

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UREA DERIVATIVES AS CB1 ALLOSTERIC MODULATORS

Heteroaryl and aliphatic analogs of diarylurea-based cannabinoid 1 receptor (CB1 R) allosteric modulators of formula (I) are described. Exemplary analogs can provide improved potencies and pharmacokinetic properties. Methods of using the analogs to treat

Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators

We previously reported diarylurea derivatives as cannabinoid type-1 receptor (CB1) allosteric modulators, which were effective in attenuating cocaine-seeking behavior. Herein, we extended the structure-activity relationships of PSNCBAM-1 (2) at the central phenyl ring directly connected to the urea moiety. Replacement with a thiophene ring led to 11 with improved or comparable potencies in calcium mobilization, [35S]GTPγS binding, and cAMP assays, whereas substitution with nonaromatic rings led to significant attenuation of the modulatory activity. These compounds had no inverse agonism in [35S]GTPγS binding, a characteristic that is often thought to contribute to adverse psychiatric effects. While 11 had good metabolic stability in rat liver microsomes, it showed modest solubility and blood-brain barrier permeability. Compound 11 showed an insignificant attenuation of cocaine seeking behavior in rats, most likely due to its limited CNS penetration, suggesting that pharmacokinetics and distribution play a role in translating the in vitro efficacy to in vivo behavior.

COMPOUNDS

A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT), Anima