tert-butyl 9-[3-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate

Base Information

Chemical Name:tert-butyl 9-[3-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate
CAS No.:912461-49-5
Molecular Formula:C₂₈H₃₈N₂O₄
Molecular Weight:466.621
Hs Code.:

Synonyms:tert-butyl 9-[3-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate

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Chemical Property of tert-butyl 9-[3-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate

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Technology Process of tert-butyl 9-[3-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate

There total 4 articles about tert-butyl 9-[3-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 236406-47-6
3,9-diazaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester hydrochloride

: 66855-92-3
3-(2-methoxyphenoxy)benzaldehyde

: 912461-49-5
tert-butyl 9-[3-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In acetonitrile; Heating / reflux;

Reference yield:

: 66855-92-3
3-(2-methoxyphenoxy)benzaldehyde

: 173405-78-2
tert-butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate

: 912461-49-5
tert-butyl 9-[3-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate

Guidance literature:: With sodium triacetoxyborohydride; acetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm900713y

Reference yield:

: 87199-16-4
3-Formylphenylboronic acid

: 912461-49-5
tert-butyl 9-[3-(2-methoxyphenoxy)benzyl]-3,9-diazaspiro[5.5]undecane-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; copper diacetate / dichloromethane / 20 °C / Molecular sieve

2: sodium tris(acetoxy)borohydride; triethylamine / acetonitrile / Heating / reflux

With pyridine; copper diacetate; sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; acetonitrile;